Sarcopenia and post-operative morbidity and mortality in patients with gastric cancer

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dc.contributor.author O'Brien, Stephen
dc.contributor.author Twomey, Maria
dc.contributor.author Moloney, Fiachra
dc.contributor.author Kavanagh, Richard G.
dc.contributor.author Carey, Brian W.
dc.contributor.author Power, Derek
dc.contributor.author Maher, Michael M.
dc.contributor.author O'Connor, Owen J.
dc.contributor.author Ó Súilleabháin, Criostoir
dc.date.accessioned 2018-12-11T16:25:02Z
dc.date.available 2018-12-11T16:25:02Z
dc.date.issued 2018-09-05
dc.identifier.citation O'Brien, S., Twomey, M., Moloney, F., Kavanagh, R. G., Carey, B. W., Power, D., Maher, M. M., O'Connor, O. J. and Ó'Súilleabháin, C. (2018) 'Sarcopenia and Post-Operative Morbidity and Mortality in Patients with Gastric Cancer', Journal of Gastric Cancer, 18(3), pp. 242-252. doi: 10.5230/jgc.2018.18.e25 en
dc.identifier.volume 18 en
dc.identifier.issued 3 en
dc.identifier.startpage 242 en
dc.identifier.endpage 252 en
dc.identifier.issn 2093-582X
dc.identifier.issn 2093-5641
dc.identifier.uri http://hdl.handle.net/10468/7198
dc.identifier.doi 10.5230/jgc.2018.18.e25
dc.description.abstract Purpose: Surgical resection for gastric adenocarcinoma is associated with significant post-operative morbidity and mortality. The aim of this study was to assess the prognostic significance of sarcopenia in patients undergoing resection for gastric adenocarcinoma with respect to post-operative morbidity and survival. Materials and Methods: A retrospective analysis was conducted on a cohort of consecutive patients who underwent surgical resection for gastric adenocarcinoma between 2008 and 2014. Patient demographics, radiological parameters, and pathological data were collected. OsiriX software (Pixmeo) was used to measure skeletal muscle area, which was normalized for height to calculate skeletal muscle index. Results: A total of 56 patients (41 male, 15 female; mean age, 68.4 ± 11.9 years) met the inclusion criteria. Of these, 36% (20 of 56) of the patients were sarcopenic pre-operatively. Both sarcopenic and non-sarcopenic patient groups were equally matched with the exception of weight and body mass index (P=0.036 and 0.001, respectively). Sarcopenia was associated with a decreased overall survival (log-rank P=0.003) and was an adverse prognostic predictor of overall survival in multivariate analysis (hazard ratio, 10.915; P=0.001). Sarcopenia was a predictor of serious in-hospital complications in multivariate analysis (odds ratio, 3.508; P=0.042). Conclusions: In patients undergoing curative resection for gastric cancer, there was a statistically significant association between sarcopenia and both decreased overall survival and serious post-operative complications. The measurement and reporting of skeletal muscle index on pre-operative computed tomography should be considered. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Korean Gastric Cancer Association en
dc.relation.uri https://jgc-online.org/DOIx.php?id=10.5230/jgc.2018.18.e25
dc.rights © 2018. Korean Gastric Cancer Association. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. en
dc.subject Sarcopenia en
dc.subject Gastric cancer en
dc.subject Stomach neoplasms en
dc.subject Prognosis en
dc.subject Morbidity en
dc.subject Tomography, X-ray computed en
dc.title Sarcopenia and post-operative morbidity and mortality in patients with gastric cancer en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Owen J. O'Connor, Medicine , University College Cork, Cork, Ireland. +353-21-490-3000 Email: oj.oconnor@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2018-12-11T16:19:39Z
dc.description.version Published Version en
dc.internal.rssid 456481333
dc.description.status Peer reviewed en
dc.identifier.journaltitle Journal of Gastric Cancer en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress oj.oconnor@ucc.ie en


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