Penicillin-binding proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in beta-lactam sensitivity of Listeria monocytogenes

Files in this item

Icon
Name: VDVS_PenicillinPV ...
Size: 740.6Kb
Format: PDF
Description: Published Version
View/Open

Penicillin-binding proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in beta-lactam sensitivity of Listeria monocytogenes

Van de Velde, Sébastien; Carryn, Stéphane; Van Bambeke, Françoise; Hill, Colin; Tulkens, Paul M.; Sleator, Roy D.
Date: 2009-12-15
Copyright: © 2009 Van de Velde et al; licensee BioMed Central Ltd.
Copyright information: http://creativecommons.org/licenses/by/2.0
Related: http://www.gutpathogens.com/content/1/1/23
Citation: Van de Velde, S. and Carryn, S. and Van Bambeke, F. and Hill, C. and Tulkens, P.M. and Sleator, R.D. (2009) 'Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes'. Gut pathogens, 1:23 doi: 10.1186/1757-4749-1-23
Published Version: 10.1186/1757-4749-1-23

Abstract:

While seven penicillin-binding proteins (PBPs) or PBP-like proteins have been identified either by radiolabelled penicillin binding studies or genomic analysis, only PBP3 has been considered of interest for Beta-lactams activity against Listeria monocytogenes. Herein we reveal that both PBP4 and Lmo0441 (a PBP-like protein) play a direct role in cephalosporin activity in L. monocytogenes while PBP4 additionally has a protective affect against both penicillin and carbapenem.

Show full item record

This item appears in the following Collection(s)

© 2009 Van de Velde et al; licensee BioMed Central Ltd. Except where otherwise noted, this item's license is described as © 2009 Van de Velde et al; licensee BioMed Central Ltd.
This website uses cookies. By using this website, you consent to the use of cookies in accordance with the UCC Privacy and Cookies Statement. For more information about cookies and how you can disable them, visit our Privacy and Cookies statement