Penicillin-binding proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in beta-lactam sensitivity of Listeria monocytogenes

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Penicillin-binding proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in beta-lactam sensitivity of Listeria monocytogenes

Van de Velde, Sébastien; Carryn, Stéphane; Van Bambeke, Françoise; Hill, Colin; Tulkens, Paul M.; Sleator, Roy D.
Date: 2009-12-15
Copyright: © 2009 Van de Velde et al; licensee BioMed Central Ltd.
Copyright information: http://creativecommons.org/licenses/by/2.0
Related: http://www.gutpathogens.com/content/1/1/23
Citation: Van de Velde, S. and Carryn, S. and Van Bambeke, F. and Hill, C. and Tulkens, P.M. and Sleator, R.D. (2009) 'Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes'. Gut pathogens, 1:23 doi: 10.1186/1757-4749-1-23
Published Version: 10.1186/1757-4749-1-23

Abstract:

While seven penicillin-binding proteins (PBPs) or PBP-like proteins have been identified either by radiolabelled penicillin binding studies or genomic analysis, only PBP3 has been considered of interest for Beta-lactams activity against Listeria monocytogenes. Herein we reveal that both PBP4 and Lmo0441 (a PBP-like protein) play a direct role in cephalosporin activity in L. monocytogenes while PBP4 additionally has a protective affect against both penicillin and carbapenem.

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© 2009 Van de Velde et al; licensee BioMed Central Ltd. Except where otherwise noted, this item's license is described as © 2009 Van de Velde et al; licensee BioMed Central Ltd.
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