Penicillin-binding proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in beta-lactam sensitivity of Listeria monocytogenes

Van de Velde, Sébastien; Carryn, Stéphane; Van Bambeke, Françoise; Hill, Colin; Tulkens, Paul M.; Sleator, Roy D.

Penicillin-binding proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in beta-lactam sensitivity of Listeria monocytogenes

Files

VDVS_PenicillinPV2009.pdf(740.61 KB)

Published Version

Date

2009-12-15

Authors

Van de Velde, Sébastien

Carryn, Stéphane

Van Bambeke, Françoise

Hill, Colin

Tulkens, Paul M.

Sleator, Roy D.

Publisher

BioMed Central

Published Version

10.1186/1757-4749-1-23

Abstract

While seven penicillin-binding proteins (PBPs) or PBP-like proteins have been identified either by radiolabelled penicillin binding studies or genomic analysis, only PBP3 has been considered of interest for Beta-lactams activity against Listeria monocytogenes. Herein we reveal that both PBP4 and Lmo0441 (a PBP-like protein) play a direct role in cephalosporin activity in L. monocytogenes while PBP4 additionally has a protective affect against both penicillin and carbapenem.

Keywords

Penicillin , Penicillin-Binding , Listeria monocytogenes , Cephalosporin , Carbapenem , Radiolabelled

Citation

Van de Velde, S. and Carryn, S. and Van Bambeke, F. and Hill, C. and Tulkens, P.M. and Sleator, R.D. (2009) 'Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes'. Gut pathogens, 1:23 doi: 10.1186/1757-4749-1-23