Differences in biocompatibility of microneedles from cyclic olefin polymers with human endothelial and epithelial skin cells

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dc.contributor.author Schossleitner, Klaudia
dc.contributor.author O'Mahony, Conor
dc.contributor.author Brandstätter, Stefan
dc.contributor.author Haslinger, Michael J.
dc.contributor.author Demuth, Sabrina
dc.contributor.author Fechtig, Daniel
dc.contributor.author Petzelbauer, Peter
dc.date.accessioned 2019-07-16T15:44:46Z
dc.date.available 2019-07-16T15:44:46Z
dc.date.issued 2018-11-19
dc.identifier.citation Schossleitner, K., O'Mahony, C., Brandstätter, S., Haslinger, M.J., Demuth, S., Fechtig, D. and Petzelbauer, P., 2019. Differences in biocompatibility of microneedles from cyclic olefin polymers with human endothelial and epithelial skin cells. Journal of Biomedical Materials Research Part A, 107(3), 505-512. DOI:10.1002/jbm.a.36565 en
dc.identifier.volume 107 en
dc.identifier.issued 3 en
dc.identifier.startpage 505 en
dc.identifier.endpage 512 en
dc.identifier.issn 0021-9304
dc.identifier.uri http://hdl.handle.net/10468/8177
dc.identifier.doi 10.1002/jbm.a.36565 en
dc.description.abstract Microneedles are promising devices for transdermal delivery and diagnostic applications, due to their minimally invasive and painless nature of application. However, so far, applications are limited to small scale research projects. Material selection and production for larger projects remain a challenge. In vitro testing using human cell culture could bridge the gap between cost effective screening of suitable materials and concerns for safety and ethics. In this study, materials were tested for effects on viability and morphology of human endothelial cells and keratinocytes. In addition, materials were assessed for their potential to influence cellular differentiation and barrier formation. Elution-based testing of inflammatory markers revealed no negative effects in all applied tests, whereas the assessment of differentiation markers on cells in direct contact with the material showed differences and allowed the selection of candidate materials for future medical device applications. This study illustrates that elution-based biocompatibility testing can paint an incomplete picture. Advanced staining techniques and cell types specific for the application of the medical device improve material selection to reduce and replace animal testing at an early stage in the development process. © 2018 The Authors. journal Of Biomedical Materials Research Part A Published By Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 505–512, 2019. en
dc.description.sponsorship Österreichische Forschungsförderungsgesellschaft (Project 853482 Microneedle) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher John Wiley and Sons Inc. en
dc.relation.uri https://onlinelibrary.wiley.com/doi/full/10.1002/jbm.a.36565
dc.rights © 2018 The Authors. Journal of Biomedical Materials Research Part A published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. en
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/ en
dc.subject Microneedle en
dc.subject Biocompatibility en
dc.subject Keratinocytes en
dc.subject Replacement en
dc.subject Cyclic olefin polymer en
dc.title Differences in biocompatibility of microneedles from cyclic olefin polymers with human endothelial and epithelial skin cells en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Conor O'Mahony, Tyndall National Institute, University College Cork, Cork, Ireland. +353-21-490-3000 Email: conor.omahony@tyndall.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Österreichische Forschungsförderungsgesellschaft en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Journal of Biomedical Materials Research Part A en
dc.internal.IRISemailaddress conor.omahony@tyndall.ie en
dc.identifier.eissn 1097-4636


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© 2018 The Authors. Journal of Biomedical Materials Research Part A published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. Except where otherwise noted, this item's license is described as © 2018 The Authors. Journal of Biomedical Materials Research Part A published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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