Scaffold-based delivery of nucleic acid therapeutics for enhanced bone and cartilage repair

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dc.contributor.author Kelly, Domhnall C.
dc.contributor.author Raftery, Rosanne M.
dc.contributor.author Curtin, Caroline M.
dc.contributor.author O'Driscoll, Caitríona M.
dc.contributor.author O'Brien, Fergal J.
dc.date.accessioned 2019-08-29T08:58:26Z
dc.date.available 2019-08-29T08:58:26Z
dc.date.issued 2019-05-01
dc.identifier.citation Kelly, D. C., Raftery, R. M., Curtin, C. M., O’Driscoll, C. M. and O’Brien, F. J. (2019) 'Scaffold-Based Delivery of Nucleic Acid Therapeutics for Enhanced Bone and Cartilage Repair', Journal of Orthopaedic Research, 37(8), pp. 1671-1680. doi: 10.1002/jor.24321 en
dc.identifier.volume 37 en
dc.identifier.issued 8 en
dc.identifier.startpage 1671 en
dc.identifier.endpage 1680 en
dc.identifier.issn 0736-0266
dc.identifier.uri http://hdl.handle.net/10468/8408
dc.identifier.doi 10.1002/jor.24321 en
dc.description.abstract Recent advances in tissue engineering have made progress toward the development of biomaterials capable of the delivery of growth factors, such as bone morphogenetic proteins, in order to promote enhanced tissue repair. However, controlling the release of these growth factors on demand and within the desired localized area is a significant challenge and the associated high costs and side effects of uncontrolled delivery have proven increasingly problematic in clinical orthopedics. Gene therapy may be a valuable tool to avoid the limitations of local delivery of growth factors. Following a series of setbacks in the 1990s, the field of gene therapy is now seeing improvements in safety and efficacy resulting in substantial clinical progress and a resurgence in confidence. Biomaterial scaffold‐mediated gene therapy provides a template for cell infiltration and tissue formation while promoting transfection of cells to engineer therapeutic proteins in a sustained but ultimately transient fashion. Additionally, scaffold‐mediated delivery of RNA‐based therapeutics can silence specific genes associated with orthopedic pathological states. This review will provide an overview of the current state‐of‐the‐art in the field of gene‐activated scaffolds and their use within orthopedic tissue engineering applications. en
dc.description.sponsorship Irish Research Council (Grant Number: GOIPG/2018/37) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Wiley en
dc.relation.uri https://onlinelibrary.wiley.com/doi/abs/10.1002/jor.24321
dc.rights © 2019 Orthopaedic Research Society. Published by Wiley Periodicals. This is the peer reviewed version of the following article: (2019), Scaffold‐Based Delivery of Nucleic Acid Therapeutics for Enhanced Bone and Cartilage Repair. J Orthop Res, 37: 1671-1680, which has been published in final form at https://doi.org/10.1002/jor.24321. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. en
dc.subject Biomaterials en
dc.subject Bone en
dc.subject Cartilage en
dc.subject Gene therapy en
dc.subject Orthopedic tissue engineering and repair en
dc.title Scaffold-based delivery of nucleic acid therapeutics for enhanced bone and cartilage repair en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Caitriona O'Driscoll, School Of Pharmacy, University College Cork, Cork, Ireland. +353-21-490-3000 Email: caitriona.odriscoll@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2020-05-01
dc.date.updated 2019-08-29T08:50:42Z
dc.description.version Accepted Version en
dc.internal.rssid 498427334
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder European Regional Development Fund en
dc.contributor.funder Irish Research Council en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Journal of Orthopaedic Research en
dc.internal.copyrightchecked No
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress caitriona.odriscoll@ucc.ie en
dc.internal.bibliocheck Funder check, SFI project number. Rerun.
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/13/RC/2073/IE/C�RAM - Centre for Research in Medical Devices/ en


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