Universal applicator for digitally-controlled pressing force and impact velocity insertion of microneedles into skin

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dc.contributor.author Leone, Mara
dc.contributor.author Van Oorschot, Bart H.
dc.contributor.author Nejadnik, M. Reza
dc.contributor.author Bocchino, Andrea
dc.contributor.author Rosato, Matteo
dc.contributor.author Kersten, Gideon
dc.contributor.author O'Mahony, Conor
dc.contributor.author Bouwstra, Joke
dc.contributor.author Van der Maaden, Koen
dc.date.accessioned 2019-09-04T08:19:40Z
dc.date.available 2019-09-04T08:19:40Z
dc.date.issued 2018-11-01
dc.identifier.citation Leone, M., van Oorschot, B., Nejadnik, M., Bocchino, A., Rosato, M., Kersten, G., O’Mahony, C., Bouwstra, J. and van der Maaden, K., 2018. Universal applicator for digitally-controlled pressing force and impact velocity insertion of microneedles into skin. Pharmaceutics, 10(4), (211). DOI:10.3390/pharmaceutics10040211 en
dc.identifier.volume 10 en
dc.identifier.issued 4 en
dc.identifier.startpage 1 en
dc.identifier.endpage 18 en
dc.identifier.uri http://hdl.handle.net/10468/8445
dc.identifier.doi 10.3390/pharmaceutics10040211 en
dc.description.abstract Microneedle technologies have been developed for dermal drug and vaccine delivery, including hollow-, solid-, coated-, and dissolving microneedles. Microneedles have been made in many different geometries and of many different materials, all of which may influence their skin-penetrating ability. To ensure reproducible and effective drug and vaccine delivery via microneedles, the optimal insertion parameters should be known. Therefore, a digitally-controlled microneedle applicator was developed to insert microneedles into the skin via impact insertion (velocity) or via pressing force insertion. Six microneedle arrays with different geometries and/or materials were applied onto ex vivo human skin with varying velocities or pressing forces. Penetration efficiency and delivered antigen dose into the skin after application of microneedles were determined. In general, microneedles pierced the skin more efficiently when applied by impact application as compared to application via pressing force. However, the angle of application of the applicator on the skin can affect the velocity of the impact, influencing the penetration efficiency of microneedles. Regarding the antigen delivery into the skin, the delivered dose was increasing by increasing the velocity or pressure, and thus, increasing the penetration efficiency. These data demonstrate that an applicator is an important tool to determine optimal application conditions with ex vivo human skin. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher MDPI en
dc.relation.uri https://www.mdpi.com/1999-4923/10/4/211
dc.rights © 2018 by the authors. Licensee MDPI, Basel, Switzerland en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Microneedle arrays en
dc.subject Impact applicator en
dc.subject Pressing force applicator en
dc.subject Skin penetration en
dc.subject (Trans)dermal drug/vaccine delivery en
dc.title Universal applicator for digitally-controlled pressing force and impact velocity insertion of microneedles into skin en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Andrea Bocchino, Tyndall National Institute, University College Cork, Cork, Ireland. +353-21-490-3000 Email: andrea.bocchino@tyndall.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Pharmaceutics en
dc.internal.IRISemailaddress andrea.bocchino@tyndall.ie en
dc.internal.IRISemailaddress conor.omahony@tyndall.ie en
dc.identifier.articleid 211 en
dc.identifier.eissn 1999-4923


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© 2018 by the authors. Licensee MDPI, Basel, Switzerland Except where otherwise noted, this item's license is described as © 2018 by the authors. Licensee MDPI, Basel, Switzerland
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