• The neurobiological effects of naturally-derived polyphenols and phospholipids in cellular & animal models of stress 

  Donoso, Francisco (University College Cork, 2019-12-20)

  The molecular and cellular basis of stress neurobiology remain an important research question in clinical science. Indeed, stress-related mental disorders, including depression and anxiety, are currently a major public ...
• Gut microbiome-mediated modulation of hepatic cytochrome P450 and P-glycoprotein: impact of butyrate and fructo-oligosaccharide-inulin 

  Walsh, Jacinta; Gheorghe, Cassandra E.; Lyte, Joshua M.; van de Wouw, Marcel; Boehme, Marcus; Dinan, Timothy G.; Cryan, John F.; Griffin, Brendan T.; Clarke, Gerard; Hyland, Niall P. (Wiley, 2020-04-26)

  Objectives: Our objective was to demonstrate microbial regulation of hepatic genes implicated in drug metabolism and transport using germ‐free (GF) mice and to explore the impact of a microbial metabolite, butyrate, and a ...
• Polyphenols selectively reverse early-life stress-induced behavioural, neurochemical and microbiota changes in the rat 

  Donoso, Francisco; Egerton, Sian; Bastiaanssen, Thomaz F. S.; Fitzgerald, Patrick; Gite, Snehal; Fouhy, Fiona; Ross, R. Paul; Stanton, Catherine; Dinan, Timothy G.; Cryan, John F. (Elsevier Ltd., 2020-04-10)

  There is a growing emphasis on the role of the microbiota-gut-brain axis as modulator of host behaviour and as therapeutic target for neuropsychiatric disorders. In addition, accumulating evidence suggests that early-life ...
• When rhythms meet the blues: Circadian interactions with the microbiota-gut-brain axis 

  Teichman, Emily M.; O'Riordan, Kenneth J.; Gahan, Cormac G. M.; Dinan, Timothy G.; Cryan, John F. (Elsevier Inc., 2020-03-03)

  The microbiota-gut-brain axis encompasses a bidirectional mode of communication between the microorganisms residing in our gut, and our brain function and behavior. The composition of the gut microbiota is subject to diurnal ...
• No effect of a musical intervention on stress response to venepuncture in a neonatal population 

  Howard, Caoimhe; Powell, Anna S.; Pavlidis, Elena; Pavel, Andreea; Finn, Daragh; Allen, Andrew; Olavarría-Ramírez, Loreto; Clarke, Gerard; Livingstone, Vicki; Boylan, Geraldine B.; Dempsey, Eugene M. (Wiley, 2019-09-18)

  Aim: To investigate the effect of a musical intervention on neonatal stress response to venepuncture as measured by salivary cortisol levels and pain profile scores. Methods: In a randomised control crossover trial, ...

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