Lung cancer in young patients: tumour characteristics and treatment in an Irish population

Show simple item record Cullivan, Sarah Ní Mhaolcatha, Sarah Henry, Michael T. Muhammad, Nazri Kaderi Mullally, William Bambury, Richard M. Burke, Louise Kennedy, Marcus P. 2019-09-09T14:55:51Z 2019-09-09T14:55:51Z 2019-08
dc.identifier.citation Cullivan, S., Ní Mhaolcatha, S., Henry, M. T., Muhammad, N. K., Mullally, W., Bambury, R. M., Burke, L. and Kennedy, M. P. (2019) 'Lung cancer in young patients: tumour characteristics and treatment in an Irish population', Translational Cancer Research, 8(4), pp. 1109-1115. doi: 10.21037/tcr.2019.06.22 en
dc.identifier.volume 8 en
dc.identifier.issued 4 en
dc.identifier.startpage 1109 en
dc.identifier.endpage 1115 en
dc.identifier.issn 2219-6803
dc.identifier.doi 10.21037/tcr.2019.06.22 en
dc.description.abstract Background: Lung cancer is the leading cause of cancer death in both sexes in Ireland. Studies suggest that lung cancer in younger patients has distinct characteristics. The aim of this study is to define the characteristics of lung cancer in patients 55-year-old or younger in an Irish population. Methods: Data was collected retrospectively from local medical records and the hospital electronic database regarding all patients diagnosed with lung cancer aged 55-year-old and younger, from 2010–2016. Information regarding patient demographics, smoking status, tumour histology, molecular analysis, stage and location, diagnostic modality and initial treatment choice was collected. In all cases the diagnosis of lung cancer was confirmed at the regional lung cancer multidisciplinary team (MDT) meeting. Results: In total, 8% (n=130) of all cases of lung cancer diagnosed from 2010 to 2016 in our center occurred in patients aged 55 years old or younger; 83% (n=108) were 45 to 55-year-old, 15% (n=19) were 35 to 44-year-old and 2% (n=3) were younger than 35-year-old; 88% (n=115) of patients reported a smoking history. There was a female preponderance (58%, n=76), higher rates of NSCLC non-squamous subtype (53%, n=69) and an upper lobe predominance (42%, n=54); 53% (n=68) of patients had IV or extensive disease at presentation. Epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK) and Kirsten rat sarcoma oncogene (KRAS) mutation rates were 9% (n=4) and 3% (n=1) and 80% (n=4) respectively. Conclusions: Lung cancer in younger patients has distinct characteristics. This study suggests a female preponderance, high smoking rates and a predilection for the upper lobes. Further large-scale multicenter studies are required to verify these results and to clarify the responsible mechanisms. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher AME Publishing Company en
dc.rights © Translational Cancer Research. All rights reserved. en
dc.subject Lung cancer en
dc.subject Younger patients en
dc.subject Upper lobe en
dc.title Lung cancer in young patients: tumour characteristics and treatment in an Irish population en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Marcus Kennedy, Medicine, University College Cork, Cork, Ireland. +353-21-490-3000 Email: en
dc.internal.availability Full text available en 2019-09-09T14:51:52Z
dc.description.version Accepted Version en
dc.internal.rssid 499773632
dc.description.status Peer reviewed en
dc.identifier.journaltitle Translational Cancer Research en
dc.internal.copyrightchecked No
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress en

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