Study protocol: a randomised controlled trial on the clinical effects of levothyroxine treatment for subclinical hypothyroidism in people aged 80 years and over

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Study protocol: a randomised controlled trial on the clinical effects of levothyroxine treatment for subclinical hypothyroidism in people aged 80 years and over

Du Puy, R. S.; Postmus, I.; Stott, D. J.; Blum, M. R.; Poortvliet, R. K. E.; Den Elzen, W. P. J.; Peeters, R. P.; van Munster, B. C.; Wolffenbuttel, B. H. R.; Westendorp, R. G. J.; Kearney, Patricia M.; Ford, I.; Kean, S.; Messow, C. M.; Watt, T.; Jukema, J. W.; Dekkers, O. M.; Smit, J. W. A.; Rodondi, N.; Gussekloo, J.; Mooijaart, S. P.
Date: 2018-09-19
Copyright: © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Copyright information: https://creativecommons.org/licenses/by/4.0/
Related: https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s12902-018-0285-8
Citation: Du Puy, R.S., Postmus, I., Stott, D.J., Blum, M.R., Poortvliet, R.K.E., Den Elzen, W.P.J., Peeters, R.P., van Munster, B.C., Wolffenbuttel, B.H.R., Westendorp, R.G.J. and Kearney, P.M., 2018. Study protocol: a randomised controlled trial on the clinical effects of levothyroxine treatment for subclinical hypothyroidism in people aged 80 years and over. BMC endocrine disorders, 18(1), 67 (14pp). DOI:10.1186/s12902-018-0285-8
Published Version: 10.1186/s12902-018-0285-8

Abstract:

Subclinical hypothyroidism is common in older people and its contribution to health and disease needs to be elucidated further. Observational and clinical trial data on the clinical effects of subclinical hypothyroidism in persons aged 80 years and over is inconclusive, with some studies suggesting harm and some suggesting benefits, translating into equipoise whether levothyroxine therapy provides clinical benefits. This manuscript describes the study protocol for the Institute for Evidence-Based Medicine in Old Age (IEMO) 80-plus thyroid trial to generate the necessary evidence base.

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© The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Except where otherwise noted, this item's license is described as © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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