Study protocol: a randomised controlled trial on the clinical effects of levothyroxine treatment for subclinical hypothyroidism in people aged 80 years and over
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Supplementary file 3
Date
2018-09-19
Authors
Du Puy, R. S.
Postmus, I.
Stott, D. J.
Blum, M. R.
Poortvliet, R. K. E.
Den Elzen, W. P. J.
Peeters, R. P.
van Munster, B. C.
Wolffenbuttel, B. H. R.
Westendorp, R. G. J.
Journal Title
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Volume Title
Publisher
BioMed Central
Published Version
Abstract
Subclinical hypothyroidism is common in older people and its contribution to health and disease needs to be elucidated further. Observational and clinical trial data on the clinical effects of subclinical hypothyroidism in persons aged 80 years and over is inconclusive, with some studies suggesting harm and some suggesting benefits, translating into equipoise whether levothyroxine therapy provides clinical benefits. This manuscript describes the study protocol for the Institute for Evidence-Based Medicine in Old Age (IEMO) 80-plus thyroid trial to generate the necessary evidence base.
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Keywords
Subclinical hypothyroidism , 80-plus , Randomised controlled trial , Quality of life , Levothyroxine
Citation
Du Puy, R.S., Postmus, I., Stott, D.J., Blum, M.R., Poortvliet, R.K.E., Den Elzen, W.P.J., Peeters, R.P., van Munster, B.C., Wolffenbuttel, B.H.R., Westendorp, R.G.J. and Kearney, P.M., 2018. Study protocol: a randomised controlled trial on the clinical effects of levothyroxine treatment for subclinical hypothyroidism in people aged 80 years and over. BMC endocrine disorders, 18(1), 67 (14pp). DOI:10.1186/s12902-018-0285-8