Study protocol: a randomised controlled trial on the clinical effects of levothyroxine treatment for subclinical hypothyroidism in people aged 80 years and over

Show simple item record

dc.contributor.author Du Puy, R. S.
dc.contributor.author Postmus, I.
dc.contributor.author Stott, D. J.
dc.contributor.author Blum, M. R.
dc.contributor.author Poortvliet, R. K. E.
dc.contributor.author Den Elzen, W. P. J.
dc.contributor.author Peeters, R. P.
dc.contributor.author van Munster, B. C.
dc.contributor.author Wolffenbuttel, B. H. R.
dc.contributor.author Westendorp, R. G. J.
dc.contributor.author Kearney, Patricia. M.
dc.contributor.author Ford, I.
dc.contributor.author Kean, S.
dc.contributor.author Messow, C. M.
dc.contributor.author Watt, T.
dc.contributor.author Jukema, J. W.
dc.contributor.author Dekkers, O. M.
dc.contributor.author Smit, J. W. A.
dc.contributor.author Rodondi, N.
dc.contributor.author Gussekloo, J.
dc.contributor.author Mooijaart, S. P.
dc.date.accessioned 2019-10-02T04:44:28Z
dc.date.available 2019-10-02T04:44:28Z
dc.date.issued 2018-09-19
dc.identifier.citation Du Puy, R.S., Postmus, I., Stott, D.J., Blum, M.R., Poortvliet, R.K.E., Den Elzen, W.P.J., Peeters, R.P., van Munster, B.C., Wolffenbuttel, B.H.R., Westendorp, R.G.J. and Kearney, P.M., 2018. Study protocol: a randomised controlled trial on the clinical effects of levothyroxine treatment for subclinical hypothyroidism in people aged 80 years and over. BMC endocrine disorders, 18(1), 67 (14pp). DOI:10.1186/s12902-018-0285-8 en
dc.identifier.volume 18 en
dc.identifier.issued 1 en
dc.identifier.startpage 1 en
dc.identifier.endpage 14 en
dc.identifier.uri http://hdl.handle.net/10468/8669
dc.identifier.doi 10.1186/s12902-018-0285-8 en
dc.description.abstract Subclinical hypothyroidism is common in older people and its contribution to health and disease needs to be elucidated further. Observational and clinical trial data on the clinical effects of subclinical hypothyroidism in persons aged 80 years and over is inconclusive, with some studies suggesting harm and some suggesting benefits, translating into equipoise whether levothyroxine therapy provides clinical benefits. This manuscript describes the study protocol for the Institute for Evidence-Based Medicine in Old Age (IEMO) 80-plus thyroid trial to generate the necessary evidence base. en
dc.description.sponsorship ZonMw programme Evidence-based Medicine in Old Age (627001001); SNF (320030–150025 and 320030–172676) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher BioMed Central en
dc.relation.uri https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s12902-018-0285-8
dc.rights © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Subclinical hypothyroidism en
dc.subject 80-plus en
dc.subject Randomised controlled trial en
dc.subject Quality of life en
dc.subject Levothyroxine en
dc.title Study protocol: a randomised controlled trial on the clinical effects of levothyroxine treatment for subclinical hypothyroidism in people aged 80 years and over en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Patricia Kearney, Department of Epidemiology and Public Health, University College Cork, Cork, Ireland. +353-21-490-3000 Email: patricia.kearney@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung en
dc.contributor.funder Seventh Framework Programme en
dc.description.status Peer reviewed en
dc.identifier.journaltitle BMC Endocrine Disorders en
dc.internal.IRISemailaddress patricia.kearney@ucc.ie en
dc.identifier.articleid 67 en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::HEALTH/278148/EU/Multi-modal effects of thyroid hormone replacement for untreated older adults with subclinical hypothyroidism; a randomised placebo-controlled trial/TRUST en
dc.identifier.eissn 1472-6823


Files in this item

This item appears in the following Collection(s)

Show simple item record

© The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Except where otherwise noted, this item's license is described as © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
This website uses cookies. By using this website, you consent to the use of cookies in accordance with the UCC Privacy and Cookies Statement. For more information about cookies and how you can disable them, visit our Privacy and Cookies statement