Electrochemotherapy causes caspase-independent necrotic-like death in pancreatic cancer cells

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dc.contributor.author Fernandes, Philana
dc.contributor.author O'Donovan, Tracey R.
dc.contributor.author McKenna, Sharon L.
dc.contributor.author Forde, Patrick F.
dc.date.accessioned 2019-10-06T20:48:04Z
dc.date.available 2019-10-06T20:48:04Z
dc.date.issued 2019-08-14
dc.identifier.citation Fernandes, P., O’Donovan, T. R., McKenna, S. L. and Forde, P. F. (2019) 'Electrochemotherapy Causes Caspase-Independent Necrotic-Like Death in Pancreatic Cancer Cells', Cancers, 11(8), 1177. (21pp.) DOI: 10.3390/cancers11081177 en
dc.identifier.volume 11 en
dc.identifier.issued 8 en
dc.identifier.startpage 1 en
dc.identifier.endpage 21 en
dc.identifier.uri http://hdl.handle.net/10468/8699
dc.identifier.doi 10.3390/cancers11081177 en
dc.description.abstract Pancreatic cancer represents a major challenge in oncology. Poor permeability of the pancreas and resistance to currently available therapies are impediments to improved patient survival. By transiently increasing cell membrane porosity and increasing drug uptake, Electrochemotherapy (ECT) has the potential to overcome these issues. In this study, we have evaluated the response of human and murine pancreatic cancer cells, in vitro, to electroporation in combination with Bleomycin, Cisplatin, or Oxaliplatin (ECT). The cytotoxic actions of all three drugs are potentiated when combined with electroporation in these cells. The biochemical and morphological changes post ECT are associated with immunogenic cell death that occurs with necroptosis rather than apoptosis. Moreover, ECT-induced cell death is rescued by Nec-1 suggesting that necroptosis may play a role in cell death mediated by cancer therapies. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher MDPI en
dc.relation.isreplacedby https://www.mdpi.com/2072-6694/11/8/1177/htm
dc.rights © The Author(s) 2019. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject ECT en
dc.subject Necroptosis en
dc.subject Apoptosis en
dc.subject ICD en
dc.subject Necrostatin-1 en
dc.title Electrochemotherapy causes caspase-independent necrotic-like death in pancreatic cancer cells en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Patrick Forde, Cancer Research at UCC, Western Gateway Building, University College Cork, Cork, Ireland. +353-21-490-3000 Email:p.forde@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Pancreatic Cancer Research Fund en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Cancers en
dc.internal.IRISemailaddress p.forde@ucc.ie en
dc.identifier.articleid 1177 en
dc.identifier.eissn 2072-6694


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© The Author(s) 2019. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited Except where otherwise noted, this item's license is described as © The Author(s) 2019. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
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