The search for clinically useful biomarkers of complex disease: A data analysis perspective
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Published version
Date
2019-07-02
Authors
Considine, Elizabeth C.
Journal Title
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Volume Title
Publisher
MDPI
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Abstract
Unmet clinical diagnostic needs exist for many complex diseases, which it is hoped will be solved by the discovery of metabolomics biomarkers. However, as yet, no diagnostic tests based on metabolomics have yet been introduced to the clinic. This review is presented as a research perspective on how data analysis methods in metabolomics biomarker discovery may contribute to the failure of biomarker studies and suggests how such failures might be mitigated. The study design and data pretreatment steps are reviewed briefly in this context, and the actual data analysis step is examined more closely.
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Keywords
Complex disease , Heterogeneous disease , Biomarker discovery , Data analysis , Metabolomics , Reproducibility , Modeling , Precision medicine
Citation
Considine, E.C., 2019. The Search for Clinically Useful Biomarkers of Complex Disease: A Data Analysis Perspective. Metabolites, 9(7), 126. (14 pp.). DOI:10.3390/metabo9070126