Analysis of the impact of CD200 on neurodegeneration
Deighan, Brian F.
Downer, Eric J.
Nolan, Yvonne M.
Lynch, Marina A.
Neuroinflammation, accompanied by neuronal loss and dysfunction, is a characteristic of neurodegenerative disorders like Alzheimer’s disease (AD) and Parkinson’s disease (PD). It is well documented that inappropriate activation of glia is the primary cause of neuroinflammation (Masocha, 2009), but their role in the pathogenesis of neurodegenerative diseases is not known. However it is certainly the case that dying neurons act to stimulate glia since they release alarmins which activate pathogen recognition receptors (PRR) and therefore the possibility exists that activation of glia especially microglia, may be a consequence, rather than a cause, of neurodegenerative processes which characterize diseases like AD and PD. Understanding microglial function remains a major goal since it is widely believed that modulating glial function will provide a possible strategy for limiting the progression of neurodegenerative diseases. Consequently it is imperative to increase our understanding of the factors which control microglial function and the mechanisms by which expression of these factors are controlled.
Neuroinflammation , Pathogen recognition receptors (PRR) , Microglia , Alzheimer’s disease , Parkinson’s disease
Anne-Marie Miller, Brian F. Deighan, Eric Downer, Anthony Lyons, Petra Henrich-Noack, Yvonne Nolan and Marina A. Lynch (2011). Analysis of the Impact of CD200 on Neurodegenerative Diseases, Neurodegenerative Diseases - Processes, Prevention, Protection and Monitoring, Dr Raymond Chuen-Chung Chang (Ed.) http://dx.doi.org/10.5772/32003