Analysis of the impact of CD200 on neurodegeneration

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dc.contributor.authorMiller, Anne-Marie
dc.contributor.authorDeighan, Brian F.
dc.contributor.authorDowner, Eric J.
dc.contributor.authorLyons, Anthony
dc.contributor.authorHenric-Noak, Petra
dc.contributor.authorNolan, Yvonne M.
dc.contributor.authorLynch, Marina A.
dc.contributor.editorChuen-Chung Chang, Raymond
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHealth Research Boarden
dc.date.accessioned2013-01-22T13:18:57Z
dc.date.available2013-01-22T13:18:57Z
dc.date.copyright2011
dc.date.issued2011-12
dc.date.updated2013-01-16T13:05:05Z
dc.description.abstractNeuroinflammation, accompanied by neuronal loss and dysfunction, is a characteristic of neurodegenerative disorders like Alzheimer’s disease (AD) and Parkinson’s disease (PD). It is well documented that inappropriate activation of glia is the primary cause of neuroinflammation (Masocha, 2009), but their role in the pathogenesis of neurodegenerative diseases is not known. However it is certainly the case that dying neurons act to stimulate glia since they release alarmins which activate pathogen recognition receptors (PRR) and therefore the possibility exists that activation of glia especially microglia, may be a consequence, rather than a cause, of neurodegenerative processes which characterize diseases like AD and PD. Understanding microglial function remains a major goal since it is widely believed that modulating glial function will provide a possible strategy for limiting the progression of neurodegenerative diseases. Consequently it is imperative to increase our understanding of the factors which control microglial function and the mechanisms by which expression of these factors are controlled.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAnne-Marie Miller, Brian F. Deighan, Eric Downer, Anthony Lyons, Petra Henrich-Noack, Yvonne Nolan and Marina A. Lynch (2011). Analysis of the Impact of CD200 on Neurodegenerative Diseases, Neurodegenerative Diseases - Processes, Prevention, Protection and Monitoring, Dr Raymond Chuen-Chung Chang (Ed.) http://dx.doi.org/10.5772/32003en
dc.identifier.doi10.5772/32003
dc.identifier.endpage346en
dc.identifier.isbn978-953-307-485-6
dc.identifier.startpage323en
dc.identifier.urihttps://hdl.handle.net/10468/906
dc.language.isoenen
dc.publisherInTechen
dc.relation.ispartofNeurodegenerative Diseases - Processes, Prevention, Protection and Monitoring
dc.relation.urihttp://www.intechopen.com/books/neurodegenerative-diseases-processes-prevention-protection-and-monitoring/analysis-of-the-impact-of-cd200-on-neurodegenerative-diseases
dc.rights© The Authors 2011en
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en
dc.subjectNeuroinflammationen
dc.subjectPathogen recognition receptors (PRR)en
dc.subjectMicrogliaen
dc.subjectAlzheimer’s diseaseen
dc.subjectParkinson’s diseaseen
dc.subject.lcshNeurodegenerative diseaseen
dc.titleAnalysis of the impact of CD200 on neurodegenerationen
dc.typeBook chapteren
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