Analysis of the impact of CD200 on neurodegeneration
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Date
2011-12
Authors
Miller, Anne-Marie
Deighan, Brian F.
Downer, Eric J.
Lyons, Anthony
Henric-Noak, Petra
Nolan, Yvonne M.
Lynch, Marina A.
Journal Title
Journal ISSN
Volume Title
Publisher
InTech
Published Version
Abstract
Neuroinflammation, accompanied by neuronal loss and dysfunction, is a characteristic of
neurodegenerative disorders like Alzheimer’s disease (AD) and Parkinson’s disease (PD). It
is well documented that inappropriate activation of glia is the primary cause of
neuroinflammation (Masocha, 2009), but their role in the pathogenesis of neurodegenerative
diseases is not known. However it is certainly the case that dying neurons act to stimulate
glia since they release alarmins which activate pathogen recognition receptors (PRR) and
therefore the possibility exists that activation of glia especially microglia, may be a
consequence, rather than a cause, of neurodegenerative processes which characterize
diseases like AD and PD. Understanding microglial function remains a major goal since it is
widely believed that modulating glial function will provide a possible strategy for limiting
the progression of neurodegenerative diseases. Consequently it is imperative to increase our
understanding of the factors which control microglial function and the mechanisms by
which expression of these factors are controlled.
Description
Keywords
Neuroinflammation , Pathogen recognition receptors (PRR) , Microglia , Alzheimer’s disease , Parkinson’s disease
Citation
Anne-Marie Miller, Brian F. Deighan, Eric Downer, Anthony Lyons, Petra Henrich-Noack, Yvonne Nolan and Marina A. Lynch (2011). Analysis of the Impact of CD200 on Neurodegenerative Diseases, Neurodegenerative Diseases - Processes, Prevention, Protection and Monitoring, Dr Raymond Chuen-Chung Chang (Ed.) http://dx.doi.org/10.5772/32003