Analysis of the impact of CD200 on neurodegeneration

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dc.contributor.author Miller, Anne-Marie
dc.contributor.author Deighan, Brian F.
dc.contributor.author Downer, Eric J.
dc.contributor.author Lyons, Anthony
dc.contributor.author Henric-Noak, Petra
dc.contributor.author Nolan, Yvonne M.
dc.contributor.author Lynch, Marina A.
dc.contributor.editor Chuen-Chung Chang, Raymond
dc.date.accessioned 2013-01-22T13:18:57Z
dc.date.available 2013-01-22T13:18:57Z
dc.date.copyright 2011
dc.date.issued 2011-12
dc.identifier.citation Anne-Marie Miller, Brian F. Deighan, Eric Downer, Anthony Lyons, Petra Henrich-Noack, Yvonne Nolan and Marina A. Lynch (2011). Analysis of the Impact of CD200 on Neurodegenerative Diseases, Neurodegenerative Diseases - Processes, Prevention, Protection and Monitoring, Dr Raymond Chuen-Chung Chang (Ed.) http://dx.doi.org/10.5772/32003 en
dc.identifier.startpage 323 en
dc.identifier.endpage 346 en
dc.identifier.isbn 978-953-307-485-6
dc.identifier.uri http://hdl.handle.net/10468/906
dc.identifier.doi 10.5772/32003
dc.description.abstract Neuroinflammation, accompanied by neuronal loss and dysfunction, is a characteristic of neurodegenerative disorders like Alzheimer’s disease (AD) and Parkinson’s disease (PD). It is well documented that inappropriate activation of glia is the primary cause of neuroinflammation (Masocha, 2009), but their role in the pathogenesis of neurodegenerative diseases is not known. However it is certainly the case that dying neurons act to stimulate glia since they release alarmins which activate pathogen recognition receptors (PRR) and therefore the possibility exists that activation of glia especially microglia, may be a consequence, rather than a cause, of neurodegenerative processes which characterize diseases like AD and PD. Understanding microglial function remains a major goal since it is widely believed that modulating glial function will provide a possible strategy for limiting the progression of neurodegenerative diseases. Consequently it is imperative to increase our understanding of the factors which control microglial function and the mechanisms by which expression of these factors are controlled. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher InTech en
dc.relation.ispartof Neurodegenerative Diseases - Processes, Prevention, Protection and Monitoring
dc.relation.uri http://www.intechopen.com/books/neurodegenerative-diseases-processes-prevention-protection-and-monitoring/analysis-of-the-impact-of-cd200-on-neurodegenerative-diseases
dc.rights © The Authors 2011 en
dc.rights.uri http://creativecommons.org/licenses/by/3.0/ en
dc.subject Neuroinflammation en
dc.subject Pathogen recognition receptors (PRR) en
dc.subject Microglia en
dc.subject Alzheimer’s disease en
dc.subject Parkinson’s disease en
dc.subject.lcsh Neurodegenerative disease en
dc.title Analysis of the impact of CD200 on neurodegeneration en
dc.type Book chapter en
dc.internal.authorurl http://research.ucc.ie/profiles/C003/edowner en
dc.internal.authorcontactother Eric Downer, Department Of Anatomy & Neuroscience, University College Cork, Cork, Ireland. +353-21-490-3000 Email: edowner@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2013-01-16T13:05:05Z
dc.description.version Accepted Version en
dc.internal.rssid 191887811
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Health Research Board en
dc.description.status Peer reviewed en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.placepublication New York en
dc.internal.IRISemailaddress edowner@ucc.ie en


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