International cancer microbiome consortium consensus statement on the role of the human microbiome in carcinogenesis

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Show simple item record Scott, Alasdair J. Alexander, James L. Merrifield, Claire A. Cunningham, David Jobin, Christian Brown, Robert Alverdy, John O'Keefe, Stephen J. Gaskins, H Rex Teare, Julian Yu, Jun Hughes, David J. Verstraelen, Hans Burton, Jeremy O'Toole, Paul W. Rosenberg, Daniel W. Marchesi, Julian R. Kinross, James M. 2019-11-20T05:16:42Z 2019-11-20T05:16:42Z 2019-05-15
dc.identifier.citation Scott, A.J., Alexander, J.L., Merrifield, C.A., Cunningham, D., Jobin, C., Brown, R., Alverdy, J., O’Keefe, S.J., Gaskins, R., Teare, J. and Yu, J., 2019. International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis. Gut, (318556). DOI:10.1136/gutjnl-2019-318556 en
dc.identifier.volume 2018 en
dc.identifier.startpage 1 en
dc.identifier.endpage 9 en
dc.identifier.issn 0017-5749
dc.identifier.doi 10.1136/gutjnl-2019-318556 en
dc.description.abstract Objective In this consensus statement, an international panel of experts deliver their opinions on key questions regarding the contribution of the human microbiome to carcinogenesis.Design International experts in oncology and/or microbiome research were approached by personal communication to form a panel. A structured, iterative, methodology based around a 1-day roundtable discussion was employed to derive expert consensus on key questions in microbiome-oncology research.Results Some 18 experts convened for the roundtable discussion and five key questions were identified regarding: (1) the relevance of dysbiosis/an altered gut microbiome to carcinogenesis; (2) potential mechanisms of microbiota-induced carcinogenesis; (3) conceptual frameworks describing how the human microbiome may drive carcinogenesis; (4) causation versus association; and (5) future directions for research in the field.The panel considered that, despite mechanistic and supporting evidence from animal and human studies, there is currently no direct evidence that the human commensal microbiome is a key determinant in the aetiopathogenesis of cancer. The panel cited the lack of large longitudinal, cohort studies as a principal deciding factor and agreed that this should be a future research priority. However, while acknowledging gaps in the evidence, expert opinion was that the microbiome, alongside environmental factors and an epigenetically/genetically vulnerable host, represents one apex of a tripartite, multidirectional interactome that drives carcinogenesis.Conclusion Data from longitudinal cohort studies are needed to confirm the role of the human microbiome as a key driver in the aetiopathogenesis of cancer. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher BMJ Publishing Group en
dc.rights © Author(s) (or their employer(s)) 2019 en
dc.rights.uri en
dc.subject Cancer en
dc.subject Microbiome en
dc.subject Carcinogenesis en
dc.title International cancer microbiome consortium consensus statement on the role of the human microbiome in carcinogenesis en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Paul O'Toole, School of Microbiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Cancer Research UK en
dc.contributor.funder National Institute for Health Research en
dc.contributor.funder Biomedical Research Centre en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Gut en
dc.internal.IRISemailaddress en
dc.identifier.articleid 318556 en
dc.identifier.eissn 1468-3288

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