Concomitant deficits in working memory and fear
extinction are functionally dissociated from reduced anxiety in metabotropic glutamate receptor 7-deficient mice
Concomitant deficits in working memory and fear
extinction are functionally dissociated from reduced anxiety in metabotropic glutamate receptor 7-deficient mice
Callaerts-Vegh, Zsuzsanna; Beckers, Tom; Ball, Simon M.; Baeyens, Frank; Callaerts, Patrick F.; Cryan, John F.; Molnar, Elek; D’Hooge, Rudi
Citation:CALLAERTS-VEGH, Z., BECKERS, T., BALL, S. M., BAEYENS, F., CALLAERTS, P. F., F. CRYAN, J., MOLNAR, E. & D'HOOGE, R. 2006. Concomitant Deficits in Working Memory and Fear Extinction Are Functionally Dissociated from Reduced Anxiety in Metabotropic Glutamate Receptor 7-Deficient Mice. The Journal of Neuroscience, 26, 6573-6582. doi: 10.1523/jneurosci.1497-06.2006
Metabotropic glutamate receptor 7 (mGluR7), a receptor with a distinct brain distribution and a putative role in anxiety, emotional responding, and spatial working memory, could be an interesting therapeutic target for fear and anxiety disorders. mGluR7-deficient (mGluR7 / ) mice showed essentially normal performance in tests for neuromotor and exploratory activity and passive avoidance learning but prominent anxiolytic behavior in two anxiety tests. They showed a delayed learning curve during the acquisition of the hidden-platform water maze, and three interspersed probe trials indicated that mGluR7 / mice were slower to acquire spatial information. Working memory in the water maze task and the radial arm maze was impaired in mGluR7 / mice compared with mGluR7 / . mGluR7 / mice also displayed a higher resistance to extinction of fear-elicited response suppression in a conditioned emotional
response protocol. In a non-fear-based water maze protocol, mGluR7 / mice displayed similar delayed extinction. These observed behavioral changes are probably not attributable to changes inAMPAorNMDAreceptor function because expression levels of AMPAand NMDA receptors were unaltered. Extinction of conditioned fear is an active and context-dependent form of inhibitory learning and an experimental model for therapeutic fear reduction. It appears to depend on glutamatergic and higher-level brain functions similar to
those involved in spatial working memory but functionally dissociated from those that mediate constitutional responses in anxiety tests.
This website uses cookies. By using this website, you consent to the use of cookies in accordance with the UCC Privacy and Cookies Statement. For more information about cookies and how you can disable them, visit our Privacy and Cookies statement