Can non-viral technologies knockdown the barriers to siRNA delivery and achieve the next generation of cancer therapeutics?

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dc.contributor.author Guo, Jianfeng
dc.contributor.author Bourre, Ludovic
dc.contributor.author Soden, Declan
dc.contributor.author O'Sullivan, Gerald C.
dc.contributor.author O'Driscoll, Caitríona M.
dc.date.accessioned 2013-01-29T10:16:24Z
dc.date.available 2013-01-29T10:16:24Z
dc.date.copyright 2011
dc.date.issued 2011-07
dc.identifier.citation Jianfeng Guo, Ludovic Bourre, Declan M. Soden, Gerald C. O'Sullivan, Caitriona O'Driscoll; (2011) 'Can non-viral technologies knockdown the barriers to siRNA delivery and achieve the next generation of cancer therapeutics?'. Biotechnology Advances, 29 (4):402-417. http://dx.doi.org/10.1016/j.biotechadv.2011.03.003 en
dc.identifier.volume 29 en
dc.identifier.issued 4 en
dc.identifier.startpage 402 en
dc.identifier.endpage 417 en
dc.identifier.issn 0734-9750
dc.identifier.uri http://hdl.handle.net/10468/934
dc.identifier.doi 10.1016/j.biotechadv.2011.03.003
dc.description.abstract Cancer is one of the most wide-spread diseases of modern times, with an estimated increase in the number of patients diagnosed worldwide, from 11.3 million in 2007 to 15.5 million in 2030 (www.who.int). In many cases, due to the delay in diagnosis and high increase of relapse, survival rates are low. Current therapies, including surgery, radiation and chemotherapy, have made significant progress, but they have many limitations and are far from ideal. Although immunotherapy has recently offered great promise as a new approach in cancer treatment, it is still very much in its infancy and more information on this approach is required before it can be widely applied. For these reasons effective, safe and patient-acceptable cancer therapy is still largely an unmet clinical need. Recent knowledge of the genetic basis of the disease opens up the potential for cancer gene therapeutics based on siRNA. However, the future of such gene-based therapeutics is dependent on achieving successful delivery. Extensive research is ongoing regarding the design and assessment of non-viral delivery technologies for siRNA to treat a wide range of cancers. Preliminary results on the first human Phase I trial for solid tumours, using a targeted non-viral vector, illustrate the enormous therapeutic benefits once the issue of delivery is resolved. In this review the genes regulating cancer will be discussed and potential therapeutic targets will be identified. The physiological and biochemical changes caused by tumours, and the potential to exploit this knowledge to produce bio-responsive ‘smart’ delivery systems, will be evaluated. This review will also provide a critical and comprehensive overview of the different non-viral formulation strategies under investigation for siRNA delivery, with particular emphasis on those designed to exploit the physiological environment of the disease site. In addition, a section of the review will be dedicated to pre-clinical animal models used to evaluate the stability, safety and efficacy of the delivery systems. en
dc.description.sponsorship Science Foundation Ireland ( Strategic Research Cluster Grant (Irish Drug Delivery Network)); Enterprise Ireland (Commercial Fund Technology Development Grant); Irish Research Council for Science, Engineering and Technology (Embark initiative) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier en
dc.relation.uri http://www.sciencedirect.com/science/article/pii/S073497501100036X
dc.rights Copyright © 2011, Elsevier. NOTICE: this is the author’s version of a work that was accepted for publication in International Biotechnology Advances . Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Biotechnology Advances [413, 1-2, 15 July 2011] DOI: http://dx.doi.org/10.1016/j.biotechadv.2011.03.003 en
dc.subject siRNA delivery en
dc.subject Cancer therapy en
dc.subject Non-viral vectors en
dc.subject.lcsh Cancer--Gene therapy en
dc.title Can non-viral technologies knockdown the barriers to siRNA delivery and achieve the next generation of cancer therapeutics? en
dc.type Article (peer-reviewed) en
dc.internal.authorurl http://publish.ucc.ie/researchprofiles/C019/caitrionaodriscoll en
dc.internal.authorcontactother Caitriona O'Driscoll, School Of Pharmacy, University College Cork, Cork, Ireland. +353-21-490-3000 Email: caitriona.odriscoll@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2013-01-17T10:49:56Z
dc.description.version Accepted Version en
dc.internal.rssid 99145986
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Enterprise Ireland en
dc.contributor.funder Irish Research Council for Science Engineering and Technology en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Biotechnology Advances en
dc.internal.copyrightchecked No. CORA: ROMEO - Elsevier Accepted Version and set statement. en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress caitriona.odriscoll@ucc.ie en


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