• Antitumour responses induced by a cell-based Reovirus vaccine in murine lung and melanoma models 

  Campion, Ciorsdan A.; Soden, Declan; Forde, Patrick F. (BioMed Central, 2016-07-13)

  Background: The ever increasing knowledge in the areas of cell biology, the immune system and the mechanisms of cancer are allowing a new phase of immunotherapy to develop. The aim of cancer vaccination is to activate the ...
• UBE2L6/UBCH8 and ISG15 attenuate autophagy in esophageal cancer cells 

  Falvey, Chloe M.; O'Donovan, Tracey R.; El-Mashed, Shereen; Nyhan, Michelle J.; O'Reilly, Seamus; McKenna, Sharon L. (Impact Journals, 2017-02-08)

  Esophageal cancer remains a poor prognosis cancer due to advanced stage of presentation and drug resistant disease. To understand the molecular mechanisms influencing response to chemotherapy, we examined genes that are ...
• MiR-193b promotes autophagy and non-apoptotic cell death in oesophageal cancer cells 

  Nyhan, Michelle J.; O'Donovan, Tracey R.; Boersma, Antonius W. M.; Wiemer, Erik A. C.; McKenna, Sharon L. (BioMed Central, 2016-02-15)

  Background: Successful treatment of oesophageal cancer is hampered by recurrent drug resistant disease. We have previously demonstrated the importance of apoptosis and autophagy for the recovery of oesophageal cancer cells ...
• Bacteria and tumours: causative agents or opportunistic inhabitants? 

  Cummins, Joanne; Tangney, Mark (BioMed Central, 2013-03-28)

  Associations between different bacteria and various tumours have been reported in patients for decades. Studies involving characterisation of bacteria within tumour tissues have traditionally been in the context of ...
• Oral tolerance to cancer can be abrogated by T regulatory cell inhibition 

  Whelan, Maria C.; Casey, Garrett; Larkin, John O.; Guinn, Barbara-Ann; O'Sullivan, Gerald C.; Tangney, Mark (Public Library of Science, 2014)

  Oral administration of tumour cells induces an immune hypo-responsiveness known as oral tolerance. We have previously shown that oral tolerance to a cancer is tumour antigen specific, non-cross-reactive and confers a tumour ...

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