• Function2Form Bridge - Towards synthetic protein holistic performance-prediction 

  Yallapragada, V. V. B.; Walker, Sidney P.; Devoy, Ciaran; Buckley, Stephen; Flores, Yensi; Tangney, Mark (John Wiley & Sons, Inc., 2019-10-07)

  Protein engineering and synthetic biology stand to benefit immensely from recent advances in in silico tools for structural and functional analyses of proteins. In the context of designing novel proteins, current in silico ...
• Electrochemotherapy causes caspase-independent necrotic-like death in pancreatic cancer cells 

  Fernandes, Philana; O’Donovan, Tracey R.; McKenna, Sharon L.; Forde, Patrick F. (MDPI, 2019-08-14)

  Pancreatic cancer represents a major challenge in oncology. Poor permeability of the pancreas and resistance to currently available therapies are impediments to improved patient survival. By transiently increasing cell ...
• CyBorD-DARA is potent initial induction for MM and enhances ADCP: Initial results of the 16-BCNI-001/CTRIAL-IE 16-02 study 

  O’Dwyer, M.; Henderson, R.; Naicker, S.D.; Cahill, Mary R.; Murphy, P.; Mykytiv, C.; McEllistrim, C.; Krawczyk, J.; Walsh, J.; Lenihan, E.; Kenny, T.; Hernando, A.; Hirakata, G.; Parker, I.; Kinsella, E.; Gannon, G.; Natoni, A.; Lynch, K.; Ryan, A. E. (American Society of Hematology, 2019-06-14)

  CyBorD DARA as induction is well tolerated and induces deep responses when used in conjunction with ASCT for MM.Mechanism of action studies indicate that CyBorD DARA enhances macrophage activation, which may play a role ...
• Health literacy influences men's active and passive cancer information seeking 

  Drummond, Frances J.; Reidy, Mary; Von Wagner, Christian; Livingstone, Vicki; Drennan, Jonathan; Murphy, Mike; Fowler, Colin; Saab, Mohammad M.; O' Mahony, Mairin; Hegarty, Josephine (Slack, 2019-07)

  BACKGROUND: For cancer prevention information to be effective, it must be accessible to its target populations. Prevalence of inadequate health literacy (HL) is high, but there is a dearth of information on the impact of ...
• An antitumorigenic role for the IL-33 receptor, ST2L, in colon cancer 

  O'Donnell, Charlotte; Mahmoud, Amr; Keane, Jonathan; Murphy, Carola T.; White, Declan; Carey, Sinead; O'Riordain, Micheal G.; Bennett, Michael W.; Brint, Elizabeth K.; Houston, Aileen M. (Nature Publishing Group, 2015-12-17)

  Background: Despite the importance of inflammation in cancer, the role of the cytokine IL-33, and its receptor ST2, in colon cancer is unclear. The aim of this study was to investigate the role of IL-33, and its receptor ...

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