High-flow nasal cannulae, bronchopulmonary dysplasia and retinopathy of prematurity

Healy, L. I.; Corcoran, Paul; Murphy, Brendan P.

High-flow nasal cannulae, bronchopulmonary dysplasia and retinopathy of prematurity

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High-flow-Nasal-Cannulae-Bronchopulmonary-Dysplasia.pdf(509.04 KB)

Published Version

Date

2019-09

Authors

Healy, L. I.

Corcoran, Paul

Murphy, Brendan P.

Publisher

Irish Medical Organisation

Abstract

Aims: To determine if HFNC use was associated with changes in incidence of BPD and ROP. Methods: This retrospective study examined premature infants (<30 weeks GA or <1500g) in a tertiary neonatal unit from 2010-2016. Patients were compared before and after introduction of HFNC. Further analysis of high-risk infants (<28 weeks GA or <750g or ventilated) compared those who received HFNC to those who did not across the whole period. Primary outcomes were incidence of BPD and ROP requiring surgery. Results: Incidence of BPD rose following the introduction of HFNC (82/232 (35.3%) after vs 33/251 (13.1%) before, p<0.001). On multivariate analysis, the chance of developing BPD after HFNC introduction remained higher (OR 4.353, 95% CI2.546-7.443). More infants received surgery for ROP following HFNC introduction (0/214 vs 11/205 (5.4%), p=<0.001). In the second analysis, the rate of BPD was higher in those who received HFNC (90/132 (68.1%) vs 33/153 (21.6%), p<0.001). Receiving HFNC demonstrated higher chance of BPD in multivariate analysis (OR 7.802, 95% CI 4.223-14.423). Rate of ROP surgery was higher in those who received HFNC (0/153 vs 13/134 (9.7%), p<0.001). Conclusions: In this study, use of HFNC was associated with significantly increased risk of adverse outcomes.

Keywords

High-flow nasal cannulae , HFNC , Premature , Neonatal , ROP surgery

Citation

Healy, L. I., Corcoran, P. and Murphy, B. P. (2019) 'High-flow nasal cannulae, bronchopulmonary dysplasia and retinopathy of prematurity', Irish Medical Journal, 112(8), P985 (7pp). Available at: http://imj.ie/wp-content/uploads/2019/09/High-flow-Nasal-Cannulae-Bronchopulmonary-Dysplasia.pdf (Accessed: 14 January 2020).