High-flow nasal cannulae, bronchopulmonary dysplasia and retinopathy of prematurity

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dc.contributor.author Healy, L. I.
dc.contributor.author Corcoran, Paul
dc.contributor.author Murphy, B. P.
dc.date.accessioned 2020-01-14T12:38:37Z
dc.date.available 2020-01-14T12:38:37Z
dc.date.issued 2019-09
dc.identifier.citation Healy, L. I., Corcoran, P. and Murphy, B. P. (2019) 'High-flow nasal cannulae, bronchopulmonary dysplasia and retinopathy of prematurity', Irish Medical Journal, 112(8), P985 (7pp). Available at: http://imj.ie/wp-content/uploads/2019/09/High-flow-Nasal-Cannulae-Bronchopulmonary-Dysplasia.pdf (Accessed: 14 January 2020). en
dc.identifier.volume 112 en
dc.identifier.issued 8 en
dc.identifier.startpage 1 en
dc.identifier.endpage 7 en
dc.identifier.issn 0332-3102
dc.identifier.uri http://hdl.handle.net/10468/9502
dc.description.abstract Aims: To determine if HFNC use was associated with changes in incidence of BPD and ROP. Methods: This retrospective study examined premature infants (<30 weeks GA or <1500g) in a tertiary neonatal unit from 2010-2016. Patients were compared before and after introduction of HFNC. Further analysis of high-risk infants (<28 weeks GA or <750g or ventilated) compared those who received HFNC to those who did not across the whole period. Primary outcomes were incidence of BPD and ROP requiring surgery. Results: Incidence of BPD rose following the introduction of HFNC (82/232 (35.3%) after vs 33/251 (13.1%) before, p<0.001). On multivariate analysis, the chance of developing BPD after HFNC introduction remained higher (OR 4.353, 95% CI2.546-7.443). More infants received surgery for ROP following HFNC introduction (0/214 vs 11/205 (5.4%), p=<0.001). In the second analysis, the rate of BPD was higher in those who received HFNC (90/132 (68.1%) vs 33/153 (21.6%), p<0.001). Receiving HFNC demonstrated higher chance of BPD in multivariate analysis (OR 7.802, 95% CI 4.223-14.423). Rate of ROP surgery was higher in those who received HFNC (0/153 vs 13/134 (9.7%), p<0.001). Conclusions: In this study, use of HFNC was associated with significantly increased risk of adverse outcomes. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Irish Medical Organisation en
dc.relation.uri http://imj.ie/wp-content/uploads/2019/09/High-flow-Nasal-Cannulae-Bronchopulmonary-Dysplasia.pdf
dc.rights © 2019, Irish Medical Journal. All rights reserved. en
dc.subject High-flow nasal cannulae en
dc.subject HFNC en
dc.subject Premature en
dc.subject Neonatal en
dc.subject ROP surgery en
dc.title High-flow nasal cannulae, bronchopulmonary dysplasia and retinopathy of prematurity en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Paul Corcoran, Epidemiology & Public Health, University College Cork, Cork, Ireland. +353-21-490-3000 Email: pcorcoran@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2020-01-14T12:30:22Z
dc.description.version Published Version en
dc.internal.rssid 499917323
dc.description.status Peer reviewed en
dc.identifier.journaltitle Irish Medical Journal en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress pcorcoran@ucc.ie en
dc.identifier.articleid P985 en


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