Differential effects of adolescent and adult-initiated exercise on cognition and hippocampal neurogenesis

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dc.contributor.author O'Leary, James D.
dc.contributor.author Hoban, Alan E.
dc.contributor.author Murphy, Ashley
dc.contributor.author O'Leary, Olivia F.
dc.contributor.author Cryan, John F.
dc.contributor.author Nolan, Yvonne M.
dc.date.accessioned 2020-02-13T15:28:40Z
dc.date.available 2020-02-13T15:28:40Z
dc.date.issued 2019-09-22
dc.identifier.citation O'Leary, J. D., Hoban, A. E., Murphy, A., O'Leary, O. F., Cryan, J. F. and Nolan, Y. M. (2019) 'Differential effects of adolescent and adult-initiated exercise on cognition and hippocampal neurogenesis', Hippocampus, 29(4), pp. 352-365. doi: 10.1002/hipo.23032 en
dc.identifier.volume 29 en
dc.identifier.startpage 352 en
dc.identifier.endpage 365 en
dc.identifier.issn 1050-9631
dc.identifier.uri http://hdl.handle.net/10468/9647
dc.identifier.doi 10.1002/hipo.23032 en
dc.description.abstract Adolescence is a critical period for postnatal brain maturation and thus a time when environmental influences may affect cognitive processes in later life. Exercise during adulthood has been shown to increase hippocampal neurogenesis and enhance cognition. However, the impact of exercise initiated in adolescence on the brain and behavior in adulthood is not fully understood. The aim of this study was to compare the impact of voluntary exercise that is initiated during adolescence or early adulthood on cognitive performance in hippocampal-dependent and -independent processes using both object-based and touchscreen operant paradigms. Adult (8 week) and adolescent (4 week) male Sprague-Dawley rats had access to a running wheel (exercise) or were left undisturbed (sedentary control) for 4 weeks prior to behavioral testing and for the duration of the experiment. Results from touchscreen-based tasks showed that reversal learning was enhanced by both adult and adolescent-initiated exercise, while only exercise that began in adolescence induced a subtle but transient increase in performance on a location discrimination task. Spontaneous alternation in the Y-maze was impaired following adolescent onset exercise, while object memory was unaffected by either adult or adolescent-initiated exercise. Adolescent-initiated exercise increased the number of hippocampal DCX cells, an indicator of neurogenesis. It also promoted the complexity of neurites on DCX cells, a key process for synaptic integration, to a greater degree than adult-initiated exercise. Together the data here show that exercise during the adolescent period compared to adulthood differentially affects cognitive processes and the development of new hippocampal neurons in later life. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Wiley en
dc.rights © 2018 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: O'Leary, JD, Hoban, AE, Murphy, A, O'Leary, OF, Cryan, JF, Nolan, YM. Differential effects of adolescent and adult‐initiated exercise on cognition and hippocampal neurogenesis. Hippocampus. 2019; 29: 352– 365, which has been published in final form at https://doi.org/10.1002/hipo.23032 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. en
dc.subject Neurogenesis en
dc.subject Running en
dc.subject Touchscreen operant behavior en
dc.subject Touchscreen operant platform en
dc.subject Dentate granule cells en
dc.subject Social isolation en
dc.subject Object recognition en
dc.subject Pattern separation en
dc.subject Aerobic fitness en
dc.subject Spontaneous alternation en
dc.subject Memory impairment en
dc.subject Brain development en
dc.subject BDNF en
dc.title Differential effects of adolescent and adult-initiated exercise on cognition and hippocampal neurogenesis en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Yvonne Nolan, Department Of Anatomy & Neuroscience, University College Cork, Cork, Ireland. +353-21-490-3000 Email: y.nolan@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2020-02-13T15:21:25Z
dc.description.version Accepted Version en
dc.internal.rssid 479313204
dc.internal.wokid WOS:000461210200004
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Hippocampus en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress y.nolan@ucc.ie en
dc.internal.IRISemailaddress o.oleary@ucc.ie en
dc.internal.IRISemailaddress j.cryan@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Investigator Programme/12/IA/1537/IE/The nuclear receptor TLX as a cell intrinsic regulator underlying inflammation and stress-induced changes in hippocampal neurogenesis: relevance to cognitive disorders/ en

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