Recent advances in the understanding of the aetiology and therapeutic strategies in burning mouth syndrome: Focus on the actions of cannabinoids

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dc.contributor.author Pereira, Sónia R.
dc.contributor.author Tello Velasquez, Johana
dc.contributor.author Duggan, Sarah
dc.contributor.author Ivanisevic, Bojana
dc.contributor.author McKenna, Joseph P.
dc.contributor.author McCreary, Christine
dc.contributor.author Downer, Eric J.
dc.date.accessioned 2020-03-11T12:27:09Z
dc.date.available 2020-03-11T12:27:09Z
dc.date.issued 2020-02-24
dc.identifier.citation Pereira, S. R., Tello Velasquez, J., Duggan, S., Ivanisevic, B., McKenna, J. P., McCreary, C. and Downer, E. J. (2020) 'Recent advances in the understanding of the aetiology and therapeutic strategies in burning mouth syndrome: focus on the actions of cannabinoids', European Journal of Neuroscience. doi: 10.1111/ejn.14712 en
dc.identifier.issn 0953-816X
dc.identifier.uri http://hdl.handle.net/10468/9753
dc.identifier.doi 10.1111/ejn.14712 en
dc.description.abstract Burning mouth syndrome (BMS) is a neuropathic pain disorder associated with a burning sensation on oral mucosal surfaces with frequently reported xerostomia, dysgeusia and tingling or paraesthetic sensations. However, patients present no clinically evident causative lesions. The poor classification of the disorder has resulted in a diagnostic challenge, particularly for the clinician/dentist evaluating these individuals. Major research developments have been made in the BMS field in recent years to address this concern, principally in terms of the pathophysiological mechanisms underlying the disorder, in addition to therapeutic advancements. For the purpose of this review, an update on the pathophysiological mechanisms will be discussed from a neuropathic, immunological, hormonal and psychological perspective. This review will also focus on the many therapeutic strategies that have been explored for BMS, including antidepressants/antipsychotics, nonsteroidal anti-inflammatories, hormone replacement therapies, phytotherapeutic compounds and non-pharmacological interventions, overall highlighting the lack of controlled clinical studies to support the effectiveness of such therapeutic avenues. Particular focus is given to the cannabinoid system, and the potential of cannabis-based therapeutics in managing BMS patients. en
dc.description.sponsorship Enterprise Ireland (IP/2018/0740) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher John Wiley & Sons, Inc. en
dc.relation.uri https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.14712
dc.rights © 2020, John Wiley & Sons, Inc. This is the peer reviewed version of the following article: Pereira, S. R., Tello Velasquez, J., Duggan, S., Ivanisevic, B., McKenna, J. P., McCreary, C. and Downer, E. J. (2020) 'Recent advances in the understanding of the aetiology and therapeutic strategies in burning mouth syndrome: focus on the actions of cannabinoids', European Journal of Neuroscience, doi: 10.1111/ejn.14712, which has been published in final form at https://doi.org/10.1111/ejn.14712. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. en
dc.subject Burning mouth syndrome en
dc.subject Cannabinoids en
dc.subject Cannabis en
dc.subject Endocannabinoid system en
dc.subject Hormonal en
dc.subject Immunological en
dc.subject Neuropathic orofacial pain en
dc.subject Psychological en
dc.subject Therapeutics en
dc.title Recent advances in the understanding of the aetiology and therapeutic strategies in burning mouth syndrome: Focus on the actions of cannabinoids en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Joseph Mc Kenna, Restorative Dentistry, University College Cork, Cork, Ireland. +353-21-490-3000 Email: j.mckenna@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2021-02-24
dc.date.updated 2020-03-11T12:15:17Z
dc.description.version Accepted Version en
dc.internal.rssid 505828046
dc.contributor.funder Enterprise Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle European Journal of Neuroscience en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress j.mckenna@ucc.ie en
dc.internal.bibliocheck In press. Check vol / issue / page range. Amend citation and copyright statement as necessary. en
dc.identifier.eissn 1460-9568


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