Dissolving microneedles: Applications and growing therapeutic potential

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dc.contributor.authorSartawi, Ziad
dc.contributor.authorBlackshields, Caroline
dc.contributor.authorFaisal, Waleed
dc.contributor.funderEnterprise Irelanden
dc.date.accessioned2022-06-14T11:01:55Z
dc.date.available2022-06-14T11:01:55Z
dc.date.issued2022-06-07
dc.date.updated2022-06-09T10:32:42Z
dc.description.abstractMicroneedles are a rapidly developing method for the transdermal delivery of therapeutic compounds. All types of microneedles, whether solid, hollow, coated, or dissolving function by penetrating the stratum corneum layer of the skin producing a microchannel through which therapeutic agents may be delivered. To date, coated and hollow microneedles have been the most successful, despite suffering from issues such as poor drug loading capabilities and blocked pores. Dissolving microneedles, on the other hand, have superior drug loading as well as other positive attributes that make it an ideal delivery system, including simple methods of fabrication and disposal, and abundantly available materials. Indeed, dissolvable microneedles can even be fabricated entirely from the therapeutic agent itself thus eliminating the requirement for additional excipients. This focused review presents the recent developments and trends of dissolving microneedles as well as potential future directions. The advantages, and disadvantages of dissolving microneedles as well as fabrication materials and methods are discussed. The potential applications of dissolving microneedles as a drug delivery system in different therapeutic areas in both research literature and clinical trials is highlighted. Applications including the delivery of cosmetics, vaccine delivery, diagnosis and monitoring, cancer, pain and inflammation, diabetes, hair and scalp disorders and inflammatory skin diseases are presented. The current trends observed in the microneedle landscape with particular emphasis on contemporary clinical trials and commercial successes as well as barriers impeding microneedle development and commercialisation are also discussed.en
dc.description.sponsorshipEnterprise Ireland (EI Commercialisation Fund, Grant Number: CF-2020-1482-I)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSartawi, Z., Blackshields, C. and Faisal, W. (2022) 'Dissolving microneedles: Applications and growing therapeutic potential', Journal Of Controlled Release, 348, pp. 186-205. doi: 10.1016/j.jconrel.2022.05.045en
dc.identifier.doi10.1016/j.jconrel.2022.05.045en
dc.identifier.endpage205en
dc.identifier.issn1873-4995
dc.identifier.journaltitleJournal Of Controlled Releaseen
dc.identifier.startpage186en
dc.identifier.urihttps://hdl.handle.net/10468/13295
dc.identifier.volume348en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0168365922003169
dc.rights© 2022 The Author(s). Published by Elsevier B. V. This is an open access article under the CC BY licenseen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectMicroneedleen
dc.subjectDissolvable microneedleen
dc.subjectSkinen
dc.subjectIntradermal deliveryen
dc.titleDissolving microneedles: Applications and growing therapeutic potentialen
dc.typeArticle (peer-reviewed)en
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