Continuous powder feeding for pharmaceutical solid dosage form manufacture: a short review

dc.check.date2018-06-17
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisher.en
dc.contributor.authorBlackshields, Caroline A.
dc.contributor.authorCrean, Abina M.
dc.contributor.funderEnterprise Irelanden
dc.contributor.funderIDA Irelanden
dc.date.accessioned2017-09-06T08:36:43Z
dc.date.available2017-09-06T08:36:43Z
dc.date.issued2017-06-17
dc.date.updated2017-09-05T11:44:54Z
dc.description.abstractThere has been a noticeable shift from pharmaceutical batch processing towards a more continuous mode of manufacture for solid oral dosage forms. Continuous solid oral dose processes would not be possible in the absence of a highly accurate feeding system. The performance of feeders defines the content of formulations and is therefore a critical operation in continuous manufacturing of solid dosage forms. It was the purpose of this review to review the role of the initial powder feeding step in a continuous manufacturing process. Different feeding mechanisms are discussed with a particular emphasis on screw controlled loss in weight (LIW) feeding. The importance of understanding the physical properties of the raw materials and its impact on the feeding process is reviewed. Prior knowledge of materials provides an initial indication of how the powders will behave through processing and facilitates in the selection of the most suitable (i) feeder (capacity), (ii) feeding mechanism, and (iii) in the case of screw feeder - screw type. The studies identified in this review focus on the impact of material on powder feeding performance.en
dc.description.sponsorshipEnterprise Ireland / IDA Ireland (Pharmaceutical Manufacturing Technology Centre Grant: TC 2013-0015)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBlackshields, C. A. and Crean, A. M. (2017) 'Continuous powder feeding for pharmaceutical solid dosage form manufacture: a short review', Pharmaceutical Development and Technology, 23(6), pp. 554-560. doi:10.1080/10837450.2017.1339197en
dc.identifier.doi10.1080/10837450.2017.1339197
dc.identifier.endpage560
dc.identifier.issn1083-7450
dc.identifier.issn1097-9867
dc.identifier.issued6
dc.identifier.journaltitlePharmaceutical Development and Technologyen
dc.identifier.startpage554
dc.identifier.urihttps://hdl.handle.net/10468/4633
dc.identifier.volume23
dc.language.isoenen
dc.publisherTaylor & Francis Groupen
dc.rights© 2017, Informa UK Limited, trading as Taylor & Francis Group. This is an Accepted Manuscript of an article published by Taylor & Francis in Pharmaceutical Development and Technology on 2017.06.17, available online: http://www.tandfonline.com/10.1080/10837450.2017.1339197en
dc.subjectContinuous manufacturingen
dc.subjectLoss-in-weight feedingen
dc.subjectPharmaceutical powder propertiesen
dc.titleContinuous powder feeding for pharmaceutical solid dosage form manufacture: a short reviewen
dc.typeArticle (peer-reviewed)en
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