Temporal evolution of quantitative EEG within 3 days of birth in early preterm infants

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dc.contributor.authorO'Toole, John M.
dc.contributor.authorPavlidis, Elena
dc.contributor.authorKorotchikova, Irina
dc.contributor.authorBoylan, Geraldine B.
dc.contributor.authorStevenson, Nathan J.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHorizon 2020en
dc.date.accessioned2019-11-19T10:20:04Z
dc.date.available2019-11-19T10:20:04Z
dc.date.issued2019-03-19
dc.description.abstractFor the premature newborn, little is known about changes in brain activity during transition to extra-uterine life. We aim to quantify these changes in relation to the longer-term maturation of the developing brain. We analysed EEG for up to 72 hours after birth from 28 infants born <32 weeks of gestation. These infants had favourable neurodevelopment at 2 years of age and were without significant neurological compromise at time of EEG monitoring. Quantitative EEG was generated using features representing EEG power, discontinuity, spectral distribution, and inter-hemispheric connectivity. We found rapid changes in cortical activity over the 3 days distinct from slower changes associated with gestational age: for many features, evolution over 1 day after birth is equivalent to approximately 1 to 2.5 weeks of maturation. Considerable changes in the EEG immediately after birth implies that postnatal adaption significantly influences cerebral activity for early preterm infants. Postnatal age, in addition to gestational age, should be considered when analysing preterm EEG within the first few days after birth.en
dc.description.sponsorship15/SIRG/3580; H2020-MCSA-IF-656131en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid4859en
dc.identifier.citationO’Toole, J.M., Pavlidis, E., Korotchikova, I., Boylan, G.B. and Stevenson, N.J., 2019. Temporal evolution of quantitative EEG within 3 days of birth in early preterm infants. Scientific reports, 9(1), (4859). DOI:10.1038/s41598-019-41227-9en
dc.identifier.doi10.1038/s41598-019-41227-9en
dc.identifier.eissn2045-2322
dc.identifier.endpage12en
dc.identifier.issued1en
dc.identifier.journaltitleScientific Reportsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9064
dc.identifier.volume9en
dc.language.isoenen
dc.publisherSpringer Natureen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/en
dc.relation.urihttps://www.nature.com/articles/s41598-019-41227-9
dc.rights© The Author(s) 2019en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectEEGen
dc.subjectPremature newbornen
dc.subjectBrain activityen
dc.titleTemporal evolution of quantitative EEG within 3 days of birth in early preterm infantsen
dc.typeArticle (peer-reviewed)en
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