Is adipose tissue a reservoir for viral spread, immune activation and cytokine amplification in COVID-19?
| dc.contributor.author | Ryan, Paul MacDaragh | |
| dc.contributor.author | Caplice, Noel M. | |
| dc.date.accessioned | 2020-04-29T09:38:50Z | |
| dc.date.available | 2020-04-29T09:38:50Z | |
| dc.date.issued | 2020-04-21 | |
| dc.date.updated | 2020-04-29T09:24:40Z | |
| dc.description.abstract | Coronavirus disease 2019 (COVID-19), the worst pandemic in more than a century, has claimed >125,000 lives worldwide to date. Emerging predictors for poor outcome include advanced age, male gender, pre-existing cardiovascular disease and risk factors including hypertension, diabetes and more recently obesity. Herein, we posit new obesity-driven predictors of poor COVID-19 outcome, over and above the more obvious extant risks associated with obesity including cardiometabolic disease and hypoventilation syndrome in intensive care patients. We outline a theoretical mechanistic framework whereby adipose tissue in subjects with obesity may act as a reservoir for more extensive viral spread with increased shedding, immune activation and cytokine amplification. We propose studies to test this reservoir concept with a focus on specific cytokine pathways that might be amplified in subjects with obesity and COVID-19. Finally, we underscore emerging therapeutic strategies that might benefit subsets of patients in which cytokine amplification is excessive and potentially fatal. | en |
| dc.description.status | Peer reviewed | en |
| dc.description.version | Accepted Version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Ryan, P. M. and Caplice, N. M. (2020) 'Is adipose tissue a reservoir for viral spread, immune activation and cytokine amplification in COVID-19?', Obesity. doi: 10.1002/oby.22843 | en |
| dc.identifier.doi | 10.1002/oby.22843 | en |
| dc.identifier.eissn | 1930-739X | |
| dc.identifier.issn | 1930-7381 | |
| dc.identifier.journaltitle | Obesity | en |
| dc.identifier.uri | https://hdl.handle.net/10468/9886 | |
| dc.language.iso | en | en |
| dc.publisher | John Wiley & Sons, Inc. | en |
| dc.rights | © 2020, the Obesity Society. Published by John Wiley & Sons, Inc. This is the peer reviewed version of the following article: Ryan, P. M. and Caplice, N. M. (2020) 'Is adipose tissue a reservoir for viral spread, immune activation and cytokine amplification in COVID-19?', Obesity, doi: 10.1002/oby.22843, which has been published in final form at https://doi.org/10.1002/oby.22843. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | en |
| dc.subject | Obesity | en |
| dc.subject | Poor COVID-19 outcome | en |
| dc.subject | Adipose tissue | en |
| dc.subject | Cytokine pathways | en |
| dc.subject | Cytokine amplification | en |
| dc.title | Is adipose tissue a reservoir for viral spread, immune activation and cytokine amplification in COVID-19? | en |
| dc.type | Article (peer-reviewed) | en |
