Explicit criteria as clinical tools to minimize inappropriate medication use and its consequences

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dc.contributor.authorCurtin, Denis
dc.contributor.authorGallagher, Paul F.
dc.contributor.authorO'Mahony, Denis
dc.contributor.funderSeventh Framework Programmeen
dc.date.accessioned2019-11-20T06:08:39Z
dc.date.available2019-11-20T06:08:39Z
dc.date.issued2019-02-13
dc.description.abstractPolypharmacy and prescribing of potentially inappropriate medications (PIMs) are the key elements of inappropriate medication use (IMU) in older multimorbid people. IMU is associated with a range of negative healthcare consequences including adverse drug events and unplanned hospitalizations. Furthermore, prescribing guidelines are commonly derived from randomized controlled clinical trials which have specifically excluded older adults with multimorbidity. Consequently, indiscriminate application of single disease pharmacotherapy guidelines to older multimorbid patients can lead to increased risk of drug?drug interactions, drug?disease interactions and poor drug adherence. Both polypharmacy and PIMs are highly prevalent in older people and strategies to improve the quality and safety of prescribing, largely through avoidance of IMU, are needed. In the last 30?years, numerous explicit PIM criteria-based tools have been developed to assist physicians with medication management in clinically complex multimorbid older people. Very few of these PIM criteria sets have been tested as an intervention compared with standard pharmaceutical care in well-designed clinical trials. In this review, we describe the most widely used sets of explicit PIM criteria to address inappropriate polypharmacy with particular focus on STOPP/START criteria and FORTA criteria which have been associated with positive patient-related outcomes when used as interventions in recent randomized controlled trials.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid2042098619829431en
dc.identifier.citationCurtin, D., Gallagher, P.F. and O’Mahony, D., 2019. Explicit criteria as clinical tools to minimize inappropriate medication use and its consequences. Therapeutic advances in drug safety, 10, (2042098619829431). DOI: 10.1177/2042098619829431en
dc.identifier.doi10.1177/2042098619829431en
dc.identifier.eissn2042-0994
dc.identifier.endpage10en
dc.identifier.issn2042-0986
dc.identifier.journaltitleTherapeutic Advances in Drug Safetyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9161
dc.identifier.volume10en
dc.language.isoenen
dc.publisherSAGE Journalsen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::HEALTH/305930/EU/Development and clinical trials of a new Software ENgine for the Assessment & Optimization of drug and non-drug Therapy in Older peRsons/SENATORen
dc.relation.urihttps://journals.sagepub.com/doi/10.1177/2042098619829431
dc.rights© The Author(s), 2019. Article reuse guidelines: sagepub.com/journalspermissionsen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectInappropriate prescribingen
dc.subjectExplicit criteriaen
dc.subjectElderlyen
dc.subjectMultimorbidityen
dc.subjectPolypharmacyen
dc.subjectAdverse drug reactionen
dc.subjectAdverse drug eventen
dc.titleExplicit criteria as clinical tools to minimize inappropriate medication use and its consequencesen
dc.typeArticle (peer-reviewed)en
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