Time resolved SPAD micro-camera probe for wide-field FLIm in microendoscopy

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Angelone, Dario
Konugolu Venkata Sekar, Sanathana
Messina, Walter
Matheson, Andrew B.
Erdogan, Ahmet T.
Henderson, Robert K.
Burke, Ray
Andersson-Engels, Stefan
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Society of Photo‑Optical Instrumentation Engineers (SPIE)
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We propose a handheld single photon avalanche diode (SPAD) micro-camera probe for wide-field in-vivo fluorescence lifetime imaging (FLIm) applications. The presented probe includes a novel 3D stacked 1.4 mm × 1.4 mm SPAD array, an integrated excitation light source, and imaging optics. The spatial and temporal performance of the integrated system was characterised using a USAF test target and range of fluorescence lifetime beads.
Fluorescence lifetime imaging , FLIm , SPAD , Micro-camera
Angelone, D., Konugolu Venkata Sekar, S., Messina, W., Matheson, A., Erdogan, A. T., Henderson, R. K., Burke, R. and Andersson-Engels, S. (2023) 'Time resolved SPAD micro-camera probe for wide-field FLIm in microendoscopy', Proceedings of SPIE, 12368, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI, 1236807 (4pp). doi: 10.1117/12.2648340
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