Fat-bone interaction within the bone marrow milieu: Impact on hematopoiesis and systemic energy metabolism

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dc.contributor.authorHawkes, Colin P.
dc.contributor.authorMostoufi-Moab, S.
dc.contributor.funderNational Institutes of Healthen
dc.date.accessioned2022-01-27T10:52:17Z
dc.date.available2022-01-27T10:52:17Z
dc.date.issued2019
dc.description.abstractThe relationship between fat, bone and systemic metabolism is a growing area of scientific interest. Marrow adipose tissue is a well-recognized component of the bone marrow milieu and is metabolically distinct from current established subtypes of adipose tissue. Despite recent advances, the functional significance of marrow adipose tissue is still not clearly delineated. Bone and fat cells share a common mesenchymal stem cell (MSC) within the bone marrow, and hormones and transcription factors such as growth hormone, leptin, and peroxisomal proliferator-activated receptor γ influence MSC differentiation into osteoblasts or adipocytes. MSC osteogenic potential is more vulnerable than adipogenic potential to radiation and chemotherapy, and this confers a risk for an abnormal fat-bone axis in survivors following cancer therapy and bone marrow transplantation. This review provides a summary of data from animal and human studies describing the relationship between marrow adipose tissue and hematopoiesis, bone mineral density, bone strength, and metabolic function. The significance of marrow adiposity in other metabolic disorders such as osteoporosis, diabetes mellitus, and estrogen and growth hormone deficiency are also discussed. We conclude that marrow adipose tissue is an active endocrine organ with important metabolic functions contributing to bone energy maintenance, osteogenesis, bone remodeling, and hematopoiesis. Future studies on the metabolic role of marrow adipose tissue may provide the critical insight necessary for selecting targeted therapeutic interventions to improve altered hematopoiesis and augment skeletal remodeling in cancer survivors. © 2018 Elsevier Inc.en
dc.description.sponsorshipNational Institutes of Health (Grant K07 CA166177)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHawkes, C. P. and Mostoufi-Moab, S. (2019) ‘Fat-bone interaction within the bone marrow milieu: Impact on hematopoiesis and systemic energy metabolism’, Bone, 119, pp.57-64. doi: 10.1016/j.bone.2018.03.012en
dc.identifier.doi10.1016/j.bone.2018.03.012
dc.identifier.endpage64
dc.identifier.issn8756-3282
dc.identifier.journaltitleBoneen
dc.identifier.startpage57
dc.identifier.urihttps://hdl.handle.net/10468/12486
dc.language.isoenen
dc.publisherElsevier Inc.en
dc.rights© 2018, Elsevier Inc. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAdipocytesen
dc.subjectAdipokinesen
dc.subjectBone marrow adipose tissueen
dc.subjectBone marrow milieuen
dc.subjectBone mineral densityen
dc.subjectHematopoeisisen
dc.subjectHematopoeitic stem cellsen
dc.subjectMesenchymal stem cellsen
dc.subjectWhite adipose tissueen
dc.titleFat-bone interaction within the bone marrow milieu: Impact on hematopoiesis and systemic energy metabolismen
dc.typeArticle (peer-reviewed)en
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