Beneficial effects of magnesium treatment on heart rate variability and cardiac ventricular function in diabetic rats

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dc.contributor.authorAmoni, Matthew
dc.contributor.authorKelly-Laubscher, Roisin
dc.contributor.authorBlackhurst, Dee
dc.contributor.authorGwanyanya, Asfree
dc.contributor.funderNational Research Foundationen
dc.contributor.funderUniversity of Capetownen
dc.contributor.funderADInstruments, Australiaen
dc.date.accessioned2022-01-27T16:43:53Z
dc.date.available2022-01-27T16:43:53Z
dc.date.issued2016-06-08
dc.date.updated2022-01-27T16:31:21Z
dc.description.abstractBackground: Diabetes mellitus induces life-threatening cardiovascular complications such as cardiac autonomic neuropathy and ventricular dysfunction and is associated with hypomagnesemia. In this study, we investigated the short-term effects of magnesium (Mg2+) treatment on streptozotocin (STZ)-induced diabetic cardiac complications. Methods: Adult Wistar rats were treated once with STZ (50 mg/kg, intraperitoneally [ip]) or vehicle (citrate) and then daily for 7 days with MgSO4 (270 mg/kg, ip) or saline. On the eighth day, in vivo tail-pulse plethysmography was recorded for heart rate variability (HRV) analysis, and ex vivo Langendorff-based left ventricular (LV) pressure–volume parameters were measured using an intraventricular balloon. Measurements of plasma lipid and Mg2+ levels as well as blood glucose and cardiac tissue Mg2+ levels were also performed. Results: Treatment with Mg2+ prevented diabetes-induced alterations in the standard deviation of the averages of normal-to-normal (NN) intervals (SDANN), root mean square differences of successive NN intervals (RMSSD), heart rate, and low-frequency (LF) power–high-frequency (HF) power ratio. In addition, Mg2+ restored orthostatic stress-induced changes in SDANN, RMSSD, and LF–HF ratio in diabetic rats. In isolated hearts, Mg2+ reversed the diabetes-induced decrease in LV end-diastolic elastance and the right shift of end-diastolic equilibrium volume intercept, without altering LV-developed pressure or end-systolic elastance. However, Mg2+ did not prevent the elevation in blood glucose, total cholesterol, and triglycerides or the decrease in high-density lipoprotein cholesterol in diabetes. Plasma- or cardiac tissue Mg2+ was not different among the treatment groups. Conclusion: These results suggest that Mg2+ treatment may attenuate diabetes-induced reduction in HRV and improve LV diastolic distensibility, without preventing hyperglycemia and dyslipidemia. Thus, Mg2+ may have a modulatory role in the early stages of diabetic cardiovascular complications.en
dc.description.sponsorshipNational Research Foundation (NRF) of South Africa (NRF (Grant No 85768), (Grant No 91514)); University of Capetown (UCT URC/Carnegie Research Development Grant); ADInstruments, Australia (Grant)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAmoni, M., Kelly-Laubscher, R., Blackhurst, D. and Gwanyanya, A. (2017) 'Beneficial Effects of Magnesium Treatment on Heart Rate Variability and Cardiac Ventricular Function in Diabetic Rats', Journal Of Cardiovascular Pharmacology And Therapeutics, 22 (2), pp. 169-178. doi: 10.1177/1074248416653831en
dc.identifier.doi10.1177/1074248416653831en
dc.identifier.endpage178en
dc.identifier.issn1074-2484
dc.identifier.issued2en
dc.identifier.journaltitleJournal Of Cardiovascular Pharmacology And Therapeuticsen
dc.identifier.startpage169en
dc.identifier.urihttps://hdl.handle.net/10468/12499
dc.identifier.volume22en
dc.language.isoenen
dc.publisherSageen
dc.relation.urihttps://journals.sagepub.com/doi/full/10.1177/1074248416653831
dc.rights© The Author(s) 2016. The Version of Record is available online at: https://doi.org/10.1177/1074248416653831en
dc.subjectCardiacen
dc.subjectDiabetesen
dc.subjectHeart rate variabilityen
dc.subjectMagnesiumen
dc.subjectPressure–volume relationshipen
dc.titleBeneficial effects of magnesium treatment on heart rate variability and cardiac ventricular function in diabetic ratsen
dc.typeArticle (peer-reviewed)en
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