Signatures of early frailty in the gut microbiota
dc.contributor.author | Jackson, Matthew A. | |
dc.contributor.author | Jeffery, Ian B. | |
dc.contributor.author | Beaumont, Michelle | |
dc.contributor.author | Bell, Jordana T. | |
dc.contributor.author | Clark, Andrew G. | |
dc.contributor.author | Ley, Ruth E. | |
dc.contributor.author | O'Toole, Paul W. | |
dc.contributor.author | Spector, Tim D. | |
dc.contributor.author | Steves, Claire J. | |
dc.contributor.funder | National Institutes of Health | en |
dc.contributor.funder | Wellcome Trust | en |
dc.contributor.funder | European Commission | en |
dc.contributor.funder | Seventh Framework Programme | en |
dc.contributor.funder | Kings College London | en |
dc.contributor.funder | National Institute for Health Research | en |
dc.contributor.funder | Guy's and St Thomas' NHS Foundation Trust | en |
dc.contributor.funder | Chronic Disease Research Foundation (CDRF), United Kingdom | en |
dc.date.accessioned | 2017-02-22T13:01:33Z | |
dc.date.available | 2017-02-22T13:01:33Z | |
dc.date.issued | 2016-01-29 | |
dc.date.updated | 2017-02-22T12:40:51Z | |
dc.description.abstract | Background: Frailty is arguably the biggest problem associated with population ageing, and associates with gut microbiome composition in elderly and care-dependent individuals. Here we characterize frailty associations with the gut microbiota in a younger community dwelling population, to identify targets for intervention to encourage healthy ageing. Method: We analysed 16S rRNA gene sequence data derived from faecal samples obtained from 728 female twins. Frailty was quantified using a frailty index (FI). Mixed effects models were used to identify associations with diversity, operational taxonomic units (OTUs) and taxa. OTU associations were replicated in the Eldermet cohort. Phenotypes were correlated with modules of OTUs collapsed by co-occurrence. Results: Frailty negatively associated with alpha diversity of the gut microbiota. Models considering a number of covariates identified 637 OTUs associated with FI. Twenty-two OTU associations were significant independent of alpha diversity. Species more abundant with frailty included Eubacterium dolichum and Eggerthella lenta. A Faecalibacterium prausnitzii OTU was less abundant in frailer individuals, and retained significance in discordant twin analysis. Sixty OTU associations were replicated in the Eldermet cohort. OTU co-occurrence modules had mutually exclusive associations between frailty and alpha diversity. Conclusions: There was a striking negative association between frailty and gut microbiota diversity, underpinned by specific taxonomic associations. Whether these relationships are causal or consequential is unknown. Nevertheless, they represent targets for diagnostic surveillance, or for intervention studies to improve vitality in ageing. | en |
dc.description.sponsorship | The TwinsUK microbiota project was funded by the National Institutes of Health (NIH) RO1 DK093595, DP2 OD007444. TwinsUK received funding from the Wellcome Trust, European Community’s Seventh Framework Programme (FP7/2007-2013), the National Institute for Health Research (NIHR)-funded BioResource, Clinical Research Facility and Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust in partnership with King’s College London. CJS is funded under a grant from the Chronic Disease Research Foundation (CDRF). Science Foundation Ireland (SFI) funds work in IBJ and PWOTs labs. | en |
dc.description.status | Peer reviewed | en |
dc.description.version | Published Version | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.citation | Jackson, M. A., Jeffery, I. B., Beaumont, M., Bell, J. T., Clark, A. G., Ley, R. E., O’Toole, P. W., Spector, T. D. and Steves, C. J. (2016) 'Signatures of early frailty in the gut microbiota', Genome Medicine, 8(1), pp. 8. doi:10.1186/s13073-016-0262-7 | en |
dc.identifier.doi | 10.1186/s13073-016-0262-7 | |
dc.identifier.endpage | 8-11 | en |
dc.identifier.issn | 1756-994X | |
dc.identifier.issued | 1 | en |
dc.identifier.journaltitle | Genome Medicine | en |
dc.identifier.startpage | 8-1 | en |
dc.identifier.uri | https://hdl.handle.net/10468/3669 | |
dc.identifier.volume | 8 | en |
dc.language.iso | en | en |
dc.publisher | BioMed Central | en |
dc.rights | © 2016 Jackson et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en |
dc.subject | Frailty | en |
dc.subject | Population ageing | en |
dc.subject | Gut microbiota | en |
dc.subject | Diagnostic surveillance | en |
dc.subject | Intervention studies | en |
dc.title | Signatures of early frailty in the gut microbiota | en |
dc.type | Article (peer-reviewed) | en |
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