Signatures of early frailty in the gut microbiota

Simple item page
dc.contributor.authorJackson, Matthew A.
dc.contributor.authorJeffery, Ian B.
dc.contributor.authorBeaumont, Michelle
dc.contributor.authorBell, Jordana T.
dc.contributor.authorClark, Andrew G.
dc.contributor.authorLey, Ruth E.
dc.contributor.authorO'Toole, Paul W.
dc.contributor.authorSpector, Tim D.
dc.contributor.authorSteves, Claire J.
dc.contributor.funderNational Institutes of Healthen
dc.contributor.funderWellcome Trusten
dc.contributor.funderEuropean Commissionen
dc.contributor.funderSeventh Framework Programmeen
dc.contributor.funderKings College Londonen
dc.contributor.funderNational Institute for Health Researchen
dc.contributor.funderGuy's and St Thomas' NHS Foundation Trusten
dc.contributor.funderChronic Disease Research Foundation (CDRF), United Kingdomen
dc.date.accessioned2017-02-22T13:01:33Z
dc.date.available2017-02-22T13:01:33Z
dc.date.issued2016-01-29
dc.date.updated2017-02-22T12:40:51Z
dc.description.abstractBackground: Frailty is arguably the biggest problem associated with population ageing, and associates with gut microbiome composition in elderly and care-dependent individuals. Here we characterize frailty associations with the gut microbiota in a younger community dwelling population, to identify targets for intervention to encourage healthy ageing. Method: We analysed 16S rRNA gene sequence data derived from faecal samples obtained from 728 female twins. Frailty was quantified using a frailty index (FI). Mixed effects models were used to identify associations with diversity, operational taxonomic units (OTUs) and taxa. OTU associations were replicated in the Eldermet cohort. Phenotypes were correlated with modules of OTUs collapsed by co-occurrence. Results: Frailty negatively associated with alpha diversity of the gut microbiota. Models considering a number of covariates identified 637 OTUs associated with FI. Twenty-two OTU associations were significant independent of alpha diversity. Species more abundant with frailty included Eubacterium dolichum and Eggerthella lenta. A Faecalibacterium prausnitzii OTU was less abundant in frailer individuals, and retained significance in discordant twin analysis. Sixty OTU associations were replicated in the Eldermet cohort. OTU co-occurrence modules had mutually exclusive associations between frailty and alpha diversity. Conclusions: There was a striking negative association between frailty and gut microbiota diversity, underpinned by specific taxonomic associations. Whether these relationships are causal or consequential is unknown. Nevertheless, they represent targets for diagnostic surveillance, or for intervention studies to improve vitality in ageing.en
dc.description.sponsorshipThe TwinsUK microbiota project was funded by the National Institutes of Health (NIH) RO1 DK093595, DP2 OD007444. TwinsUK received funding from the Wellcome Trust, European Community’s Seventh Framework Programme (FP7/2007-2013), the National Institute for Health Research (NIHR)-funded BioResource, Clinical Research Facility and Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust in partnership with King’s College London. CJS is funded under a grant from the Chronic Disease Research Foundation (CDRF). Science Foundation Ireland (SFI) funds work in IBJ and PWOTs labs.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationJackson, M. A., Jeffery, I. B., Beaumont, M., Bell, J. T., Clark, A. G., Ley, R. E., O’Toole, P. W., Spector, T. D. and Steves, C. J. (2016) 'Signatures of early frailty in the gut microbiota', Genome Medicine, 8(1), pp. 8. doi:10.1186/s13073-016-0262-7en
dc.identifier.doi10.1186/s13073-016-0262-7
dc.identifier.endpage8-11en
dc.identifier.issn1756-994X
dc.identifier.issued1en
dc.identifier.journaltitleGenome Medicineen
dc.identifier.startpage8-1en
dc.identifier.urihttps://hdl.handle.net/10468/3669
dc.identifier.volume8en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.rights© 2016 Jackson et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectFrailtyen
dc.subjectPopulation ageingen
dc.subjectGut microbiotaen
dc.subjectDiagnostic surveillanceen
dc.subjectIntervention studiesen
dc.titleSignatures of early frailty in the gut microbiotaen
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 5 of 7
Thumbnail Image
Name:
2553.pdf
Size:
1.36 MB
Format:
Adobe Portable Document Format
Description:
Published Version
Download
Thumbnail Image
Name:
2553_1.docx
Size:
12.36 KB
Format:
Microsoft Word XML
Description:
Additional File 1
Download
Thumbnail Image
Name:
2553_2.pdf
Size:
5.29 KB
Format:
Adobe Portable Document Format
Description:
Additional File 2
Download
Thumbnail Image
Name:
2553_3.xls
Size:
102 KB
Format:
Microsoft Excel
Description:
Additional File 3
Download
Thumbnail Image
Name:
2553_4.xls
Size:
24 KB
Format:
Microsoft Excel
Description:
Additional File 4
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Microbiology - Journal Articles
APC Microbiome Ireland - Journal Articles