LC-MS/MS-based metabolite profiling and functional assessment of Hydrodictyon reticulatum as a potential source of natural therapeutics collected from the Yamuna River, India

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dc.contributor.authorKumar, Dharmendra
dc.contributor.authorAgrawal, Shivakar
dc.contributor.authorPrajapati, Manisha
dc.contributor.authorSahoo, Sanjukta
dc.contributor.authorSahoo, Dinabandhu
dc.date.accessioned2026-05-26T11:00:03Z
dc.date.available2026-05-26T11:00:03Z
dc.date.issued2026-04-28
dc.description.abstractHydrodictyon , a filamentous green alga, was found across multiple sites in the Yamuna River, India, during COVID-19, forming harmful algal blooms. Its potential uses remain underexplored. This study investigates the nutraceutical, antioxidant, and antidiabetic properties of Hydrodictyon reticulatum collected from different locations. The metabolic analysis revealed the highest concentrations of carbohydrates in Haryana (24.29 ± 0.12%), reducing sugars in Baghpat (8.41 ± 0.22%), chlorophyll a in Baghpat (0.30 ± 0.06 mg/g DW), chlorophyll b in Baghpat and Katha (0.49 ± 0.08/0.02 mg/g DW), carotenoids in Baghpat (0.39 ± 0.01 mg/g DW), and flavonoids in Baghpat (13.07 ± 0.73 mg QE/g DW). The sample from Khekra exhibited the highest protein content (5.85 ± 0.13%) and phenolic content (117.57 ± 3.94 mg GAE/g DW). Lipid content, relevant for biodiesel applications, peaked in Haryana (31.47 ± 0.87%). The strongest antioxidant responses were observed for DPPH in Katha (86.45 ± 3.73%), TAC in Katha (411.80 ± 4.23 mg TAE/g DW), and FRAP in Katha (16.97 ± 0.55 µmol TE/g DW). For antidiabetic activity, the lowest (strongest) α-glucosidase IC₅₀ was recorded in Katha (0.09 ± 0.03 mg/ml), while the lowest α-amylase IC₅₀ occurred in Khekra (0.13 ± 0.01 mg/ml). LC-MS/MS analysis revealed a diverse array of bioactive compounds, including lipids, sterols, flavonoids, and phenolic acids. Combined LC-MS/MS, FTIR, and CHNS analyses highlight the antioxidant, anti-inflammatory, nutraceutical, and biodiesel potential of H. reticulatum from the Yamuna River.en
dc.description.versionPublished Version
dc.format.extent17
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid102062
dc.identifier.authororcidKumar, Dharmendra
dc.identifier.authororcidAgrawal, Shivakar§0000-0002-1584-691X
dc.identifier.authororcidPrajapati, Manisha
dc.identifier.authororcidSahoo, Sanjukta
dc.identifier.authororcidSahoo, Dinabandhu
dc.identifier.citationKumar, D, Agrawal, S, Prajapati, M, Sahoo, S & Sahoo, D 2026, 'LC-MS/MS-based metabolite profiling and functional assessment of Hydrodictyon reticulatum as a potential source of natural therapeutics collected from the Yamuna River, India', Applied Food Research, vol. 6, no. 1, 102062, pp. 1-17. https://doi.org/10.1016/j.afres.2026.102062
dc.identifier.doi10.1016/j.afres.2026.102062
dc.identifier.endpage17
dc.identifier.issn2772-5022
dc.identifier.issued1
dc.identifier.journaltitleApplied Food Research
dc.identifier.otherRIS: urn:0783DAFF20AD4E06F383EA422C3BAC8B
dc.identifier.otherORCID: /0000-0002-1584-691X/work/215854083
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/18887
dc.identifier.volume6
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.urihttps://www.scopus.com/pages/publications/105036632844
dc.relation.urihttps://www.scopus.com/pages/publications/105036632844?origin=resultslist
dc.rights© 2026, the Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ ).
dc.rights.accessrightsopen access
dc.rights.licensenameAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.statusPeer reviewed
dc.subjectAntioxidants
dc.subjectCHNS
dc.subjectFTIR
dc.subjectLCMS/MS
dc.subjectLipid
dc.subjectMetabolomics
dc.subjectPrincipal component analysis (PCA)
dc.subject[APCMicrobiome]
dc.subjectα-Amylase
dc.subjectα-Glucosidase
dc.titleLC-MS/MS-based metabolite profiling and functional assessment of Hydrodictyon reticulatum as a potential source of natural therapeutics collected from the Yamuna River, Indiaen
dc.typeArticle (peer-reviewed)
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