Sex-specific socioeconomic inequalities in trajectories of anthropometry, blood pressure, and blood-based biomarkers from birth to 18 years: a prospective cohort study

Simple item page
dc.contributor.authorO’Neill, Kate N.en
dc.contributor.authorAhmed, Minhalen
dc.contributor.authorO’Keeffe, Linda M.en
dc.contributor.funderMedical Research Councilen
dc.contributor.funderUniversity of Bristolen
dc.contributor.funderWellcome Trusten
dc.contributor.funderHealth Research Boarden
dc.date.accessioned2025-04-30T08:44:41Z
dc.date.available2025-04-30T08:44:41Z
dc.date.issued2025en
dc.description.abstractEvidence on when socioeconomic inequalities in conventional cardiometabolic risk factors emerge and how these change over time is sparse but important in identifying pathways to socioeconomic inequalities in cardiovascular disease (CVD). We examine socioeconomic inequalities in cardiometabolic risk factors trajectories across childhood and adolescence. Data were from the Avon Longitudinal Study of Parents and Children (ALSPAC), born in 1991/1992. Socioeconomic position (SEP) was measured using maternal education from questionnaires at 32-weeks’ gestation. Cardiometabolic risk factors measured from birth/mid-childhood to 18 years (y) included fat and lean mass (9–18 y), systolic and diastolic blood pressure (SBP, DBP), pulse rate and glucose (7–18 y), high-density lipoprotein cholesterol (HDL-c), non-HDL-c and triglycerides (birth–18y). Associations were examined using linear spline multilevel models. Among 6517–8952 participants with 11 948–42 607 repeated measures, socioeconomic inequalities in fat mass were evident at age 9 y and persisted throughout adolescence. By 18 y, fat mass was 12.32% [95% confidence interval (CI): 6.96, 17.68] lower among females and 7.94% (95% CI: 1.91, 13.97) lower among males with the highest SEP compared to the lowest. Socioeconomic inequalities in SBP and DBP were evident at 7 y, narrowed in early adolescence and re-emerged between 16 and 18 y, particularly among females. Socioeconomic inequalities in lipids emerged, among females only, between birth and 9 y in non-HDL-c, 7 and 18 y in HDL-c, and 9 and 18 y in triglycerides while inequalities in glucose emerged among males only between 15 and 18 y. Prevention targeting the early life course may be beneficial for reducing socioeconomic inequalities in CVD especially among females who have greater inequalities in cardiometabolic risk factors than males at the end of adolescence.en
dc.description.sponsorshipWellcome Trust (217065/Z/19/Z); Health Research Board (ILP-PHR-2022-008)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationO’Neill, K. N., Ahmed, M. and O’Keeffe, L. M. (2025) 'Sex-specific socioeconomic inequalities in trajectories of anthropometry, blood pressure, and blood-based biomarkers from birth to 18 years: a prospective cohort study', European Journal of Public Health, 35(2), pp.249-255. DOI: 10.1093/eurpub/ckaf022en
dc.identifier.doi10.1093/eurpub/ckaf022en
dc.identifier.endpage255en
dc.identifier.issn11011262en
dc.identifier.issued2
dc.identifier.journaltitleEuropean Journal of Public Healthen
dc.identifier.startpage249en
dc.identifier.urihttps://hdl.handle.net/10468/17359
dc.identifier.volume35
dc.language.isoenen
dc.publisherOxford University Pressen
dc.rights© 2025, the Author(s). Published by Oxford University Press on behalf of the European Public Health Association. Published by Oxford University Press on behalf of the European Public Health Association. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAdolescenten
dc.subjectAnthropometryen
dc.subjectBiomarkersen
dc.subjectBlood pressureen
dc.subjectCardiovascular diseasesen
dc.subjectChilden
dc.subjectChild, preschoolen
dc.subjectFemaleen
dc.subjectHealth status disparitiesen
dc.subjectHumansen
dc.subjectInfanten
dc.subjectInfant, newbornen
dc.subjectLongitudinal studiesen
dc.subjectMaleen
dc.subjectProspective studiesen
dc.subjectRisk factorsen
dc.subjectSex Factorsen
dc.subjectSocioeconomic factorsen
dc.subjectBiological markeren
dc.subjectAdolescenten
dc.subjectAnthropometryen
dc.subjectBlooden
dc.subjectBlood pressureen
dc.subjectCardiovascular diseaseen
dc.subjectChilden
dc.subjectEpidemiologyen
dc.titleSex-specific socioeconomic inequalities in trajectories of anthropometry, blood pressure, and blood-based biomarkers from birth to 18 years: a prospective cohort studyen
dc.typeArticle (peer reviewed)en
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ckaf022.pdf
Size:
1.31 MB
Format:
Adobe Portable Document Format
Description:
Published Version
Download
Collections
Public Health - Journal Articles