The relationship between the BMI-adjusted weight loss grading system and quality of life in patients with incurable cancer

Simple item page
dc.contributor.authorDaly, Louise
dc.contributor.authorDolan, Ross
dc.contributor.authorPower, Derek
dc.contributor.authorNí Bhuachalla, Éadaoin
dc.contributor.authorSim, Wei
dc.contributor.authorFallon, Marie
dc.contributor.authorCushen, Samantha J.
dc.contributor.authorSimmons, Claribel
dc.contributor.authorMcMillan, Donald C.
dc.contributor.authorLaird, Barry J.
dc.contributor.authorRyan, Aoife
dc.contributor.funderMedical Research Scotlanden
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2019-12-05T09:55:48Z
dc.date.available2019-12-05T09:55:48Z
dc.date.issued2019-11-06
dc.description.abstractBackground: Weight loss (WL) has long been recognized as an important factor associated with reduced quality of life (QoL) and reduced survival in patients with cancer. The body mass index (BMI)‐adjusted weight loss grading system (WLGS) has been shown to be associated with reduced survival. However, its impact on QoL has not been established. The aim of this study was to assess the relationship between this WLGS and QoL in patients with advanced cancer. Methods: A biobank analysis was undertaken of adult patients with advanced cancer. Data collected included patient demographics, Eastern Cooperative Oncology Group performance status, and anthropometric parameters (BMI and %WL). Patients were categorized according to the BMI‐adjusted WLGS into one of five distinct WL grades (grades 0–4). QoL was collected using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire‐C30. The Kruskal–Wallis test and multivariate logistic regression analyses were used to assess the relationship between the WLGS and QoL scores. Overall survival was assessed using Kaplan–Meier curve and Cox proportional hazard models. Results: A total of 1027 patients were assessed (51% male, median age: 66 years). Gastrointestinal cancer was most prevalent (40%), and 87% of patients had metastatic disease. Half (58%) of patients had a WL grade of 0–1, while 12%, 20%, and 10% had WL grades of 2, 3, and 4, respectively. Increasing WL grades were significantly associated with poorer QoL functioning and symptoms scales (all P < 0.05). Physical, role, and emotional functioning decreased by a median of >20 points between WL grade 0 and WL grade 4, while appetite loss, pain, dyspnoea, and fatigue increased by a median score >20 points, indicative of a large clinical significant difference. Increasing WL grades were associated with deteriorating QoL summary score. WL grades 2, 3, and 4 were independently associated with a QoL summary score below the median (<77.7) [odds ratio (OR) 1.69, P = 0.034; OR 2.06, P = 0.001; OR 4.29, P < 0.001, respectively]. WL grades 3 and 4 were independently associated with reduced overall survival [hazard ratio 1.54 (95% confidence interval: 1.22–1.93), P < 0.001 and hazard ratio 1.87 (95% confidence interval: 1.42–2.45), P < 0.001, respectively]. Conclusions: Our findings support that the WLGS is useful in identifying patients at risk of poor QoL that deteriorates with increasing WL grades. WL grade 4 is independently associated with a particularly worse prognosis and increased symptom burden. Identification and early referral to palliative care services may benefit these patients.en
dc.description.sponsorshipMedical Research Scotland (Grant Number: 487 FRG)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationDaly, L., Dolan, R., Power, D., Ní Bhuachalla, É., Sim, W., Fallon, M., Cushen, S., Simmons, C., McMillan, D. C., Laird, B. J. and Ryan, A. 'The relationship between the BMI-adjusted weight loss grading system and quality of life in patients with incurable cancer', Journal of Cachexia, Sarcopenia and Muscle, in press. (9pp.) doi: 10.1002/jcsm.12499en
dc.identifier.doi10.1002/jcsm.12499en
dc.identifier.eissn2190-6009
dc.identifier.endpage9en
dc.identifier.issn2190-5991
dc.identifier.journaltitleJournal of Cachexia, Sarcopenia and Muscleen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9333
dc.language.isoenen
dc.publisherJohn Wiley & Sons Ltd.en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rights©2019The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting DisordersJournal of Cachexia, Sarcopenia and Muscle(2019)Published online in Wiley Online Library (wileyonlinelibrary.com)DOI:10.1002/jcsm.12499This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided theoriginal work is properly citeden
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectCanceren
dc.subjectMalnutritionen
dc.subjectWeight lossen
dc.subjectCachexiaen
dc.subjectQuality of lifeen
dc.subjectSurvivalen
dc.titleThe relationship between the BMI-adjusted weight loss grading system and quality of life in patients with incurable canceren
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Daly_et_al-2019-Journal_of_Cachexia,_Sarcopenia_and_Muscle.pdf
Size:
912.97 KB
Format:
Adobe Portable Document Format
Description:
Published version
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Food and Nutritional Sciences - Journal Articles
Cancer Research @ UCC - Journal Articles