Coexistent sarcoidosis and lymphangioleiomyomatosis in a patient with cystic lung disease

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dc.contributor.authorCullivan, Sarah
dc.contributor.authorDe La Harpe Golden, Peter
dc.contributor.authorDoyle, Deirdre
dc.contributor.authorDoddakula, Kishore Kumar
dc.contributor.authorBurke, Louise
dc.contributor.authorMurphy, Desmond M.
dc.date.accessioned2019-05-13T11:11:19Z
dc.date.available2019-05-13T11:11:19Z
dc.date.issued2019
dc.description.abstractA 45-year-old lady presented acutely with pleuritic chest pain, haemoptysis, and dyspnoea. Her background was significant for a 1.4 cm renal angiomyolipoma, and she was an ex-smoker without any relevant family history. A computed tomography (CT) pulmonary angiogram was negative for a pulmonary embolism but demonstrated diffuse cystic change throughout both lungs. A bronchoscopy confirmed a normal endobronchial tree, and pulmonary function tests demonstrated moderate airways obstruction, with reversibility and a normal diffusion capacity for carbon monoxide (DLCO). A video-assisted thoracoscopic surgery (VATS) lung biopsy showed non-caseating granulomas, and serum angiotensin converting enzyme (ACE) was elevated consistent with a diagnosis of pulmonary sarcoidosis. Further sectioning indicated focal areas that stained positive for Human Melanoma Black 45 (HMB-45), confirming lymphangioleiomyomatosis (LAM). A diagnosis of cystic lung disease secondary to coexistent sarcoidosis and LAM was made.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide00389en
dc.identifier.citationCullivan, S., De La Harpe Golden, P., Doyle, D., Doddakula, K.K., Burke, L. and Murphy, D.M., 2019. Coexistent sarcoidosis and lymphangioleiomyomatosis in a patient with cystic lung disease. Respirology case reports, 7(2), (3pp.) e00389. DOI: 10.1002/rcr2.389en
dc.identifier.doi10.1002/rcr2.389en
dc.identifier.endpage3en
dc.identifier.issn2051-3380
dc.identifier.issued2en
dc.identifier.journaltitleRespirology Case Reportsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/7883
dc.identifier.volume7en
dc.language.isoenen
dc.publisherWiley-Blackwell Publishing Ltden
dc.relation.urihttps://onlinelibrary.wiley.com/doi/full/10.1002/rcr2.389
dc.rights© 2018 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectCystic lung diseaseen
dc.subjectLymphangioleiomyomatosisen
dc.subjectSarcoidosisen
dc.titleCoexistent sarcoidosis and lymphangioleiomyomatosis in a patient with cystic lung diseaseen
dc.typeArticle (peer-reviewed)en
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