Nanosize and shape effects on antimicrobial activity of silver using morphology-controlled nanopatterns by block copolymer fabrication

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dc.contributor.authorGhoshal, Tandra
dc.contributor.authorCruz-Romero, Malco C.
dc.contributor.authorKerry, Joseph P.
dc.contributor.authorMorris, Michael A.
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2020-03-31T16:08:17Z
dc.date.available2020-03-31T16:08:17Z
dc.date.issued2019-10-04
dc.date.updated2020-03-31T15:49:43Z
dc.description.abstractThe activity of silver nanomaterials as an antimicrobial is well-known with authors noting strong size and shape effects. This paper explores if the antimicrobial activity relates to unique size-related properties of the nanodimensioned materials or a more physical effect. Staphylococcus aureus and Pseudomonas aeruginosa were explored as test bacteria. They can cause serious human infections and are becoming resistant to pharmaceutical antimicrobials. Silver nanopatterns on a substrate surface were used as the antimicrobial agent. We demonstrate a cost-effective facile route to fabricate a well-ordered, periodic, and dimension-controlled silver lines and dots pattern on a substrate surface. This allowed precise definition of the silver materials to explore size and shape effects. Polystyrene-b-poly(ethylene oxide) (PS-b-PEO) block copolymer (BCP) microphase separated thin films were used as structural templates. Well-ordered PS-b-PEO thin film with vertical and parallel oriented PEO cylinders was achieved by a solvent vapor annealing approach through careful optimization of experimental parameters. A selective inclusion method (into one block of the BCP) of silver nitrate was used to generate the silver nanopatterns. Spin coating precursor-ethanol solution and subsequent UV/ozone treatment produce silver nanopattern arrays. They exhibited a significant growth-inhibitory effect on Staphylococcus aureus and Pseudomonas aeruginosa biofilms. However, data suggest this is associated with high surface area rather than a unique nanodimension related property change dictated by size or shape.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationGhoshal, T., Cruz-Romero, M. C., Kerry, J. P., Morris, M. A. (2019) 'Nanosize and Shape Effects on Antimicrobial Activity of Silver Using Morphology-Controlled Nanopatterns by Block Copolymer Fabrication', ACS Applied Nano Materials, 2 (10), pp. 6325-6333. doi: 10.1021/acsanm.9b01286en
dc.identifier.doi10.1021/acsanm.9b01286en
dc.identifier.endpage6333en
dc.identifier.issn2574-0970
dc.identifier.issued10en
dc.identifier.journaltitleAcs Applied Nano Materialsen
dc.identifier.startpage6325en
dc.identifier.urihttps://hdl.handle.net/10468/9800
dc.identifier.volume2en
dc.language.isoenen
dc.publisherAmerican Chemical Societyen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2278/IE/Advanced Materials and BioEngineering Research Centre (AMBER)/en
dc.relation.urihttps://pubs.acs.org/doi/abs/10.1021/acsanm.9b01286
dc.rights© 2019 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Nano Materials, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/abs/10.1021/acsanm.9b01286en
dc.subjectAntimicrobialen
dc.subjectBlock copolymeren
dc.subjectNanopatternsen
dc.subjectOpticalen
dc.subjectSelf-assemblyen
dc.subjectSilveren
dc.subjectSubstrateen
dc.subjectSurface areaen
dc.titleNanosize and shape effects on antimicrobial activity of silver using morphology-controlled nanopatterns by block copolymer fabricationen
dc.typeArticle (peer-reviewed)en
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