Access to this article is restricted until 12 months after publication by request of the publisher.. Restriction lift date: 2020-10-04
Nanosize and shape effects on antimicrobial activity of silver using morphology-controlled nanopatterns by block copolymer fabrication
| dc.check.date | 2020-10-04 | |
| dc.check.info | Access to this article is restricted until 12 months after publication by request of the publisher. | en |
| dc.contributor.author | Ghoshal, Tandra | |
| dc.contributor.author | Cruz-Romero, Malco C. | |
| dc.contributor.author | Kerry, Joseph P. | |
| dc.contributor.author | Morris, Michael A. | |
| dc.contributor.funder | Science Foundation Ireland | en |
| dc.date.accessioned | 2020-03-31T16:08:17Z | |
| dc.date.available | 2020-03-31T16:08:17Z | |
| dc.date.issued | 2019-10-04 | |
| dc.date.updated | 2020-03-31T15:49:43Z | |
| dc.description.abstract | The activity of silver nanomaterials as an antimicrobial is well-known with authors noting strong size and shape effects. This paper explores if the antimicrobial activity relates to unique size-related properties of the nanodimensioned materials or a more physical effect. Staphylococcus aureus and Pseudomonas aeruginosa were explored as test bacteria. They can cause serious human infections and are becoming resistant to pharmaceutical antimicrobials. Silver nanopatterns on a substrate surface were used as the antimicrobial agent. We demonstrate a cost-effective facile route to fabricate a well-ordered, periodic, and dimension-controlled silver lines and dots pattern on a substrate surface. This allowed precise definition of the silver materials to explore size and shape effects. Polystyrene-b-poly(ethylene oxide) (PS-b-PEO) block copolymer (BCP) microphase separated thin films were used as structural templates. Well-ordered PS-b-PEO thin film with vertical and parallel oriented PEO cylinders was achieved by a solvent vapor annealing approach through careful optimization of experimental parameters. A selective inclusion method (into one block of the BCP) of silver nitrate was used to generate the silver nanopatterns. Spin coating precursor-ethanol solution and subsequent UV/ozone treatment produce silver nanopattern arrays. They exhibited a significant growth-inhibitory effect on Staphylococcus aureus and Pseudomonas aeruginosa biofilms. However, data suggest this is associated with high surface area rather than a unique nanodimension related property change dictated by size or shape. | en |
| dc.description.status | Peer reviewed | en |
| dc.description.version | Accepted Version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Ghoshal, T., Cruz-Romero, M. C., Kerry, J. P., Morris, M. A. (2019) 'Nanosize and Shape Effects on Antimicrobial Activity of Silver Using Morphology-Controlled Nanopatterns by Block Copolymer Fabrication', ACS Applied Nano Materials, 2 (10), pp. 6325-6333. doi: 10.1021/acsanm.9b01286 | en |
| dc.identifier.doi | 10.1021/acsanm.9b01286 | en |
| dc.identifier.endpage | 6333 | en |
| dc.identifier.issn | 2574-0970 | |
| dc.identifier.issued | 10 | en |
| dc.identifier.journaltitle | Acs Applied Nano Materials | en |
| dc.identifier.startpage | 6325 | en |
| dc.identifier.uri | https://hdl.handle.net/10468/9800 | |
| dc.identifier.volume | 2 | en |
| dc.language.iso | en | en |
| dc.publisher | American Chemical Society | en |
| dc.relation.project | info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2278/IE/Advanced Materials and BioEngineering Research Centre (AMBER)/ | en |
| dc.relation.uri | https://pubs.acs.org/doi/abs/10.1021/acsanm.9b01286 | |
| dc.rights | © 2019 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Nano Materials, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/abs/10.1021/acsanm.9b01286 | en |
| dc.subject | Antimicrobial | en |
| dc.subject | Block copolymer | en |
| dc.subject | Nanopatterns | en |
| dc.subject | Optical | en |
| dc.subject | Self-assembly | en |
| dc.subject | Silver | en |
| dc.subject | Substrate | en |
| dc.subject | Surface area | en |
| dc.title | Nanosize and shape effects on antimicrobial activity of silver using morphology-controlled nanopatterns by block copolymer fabrication | en |
| dc.type | Article (peer-reviewed) | en |
