Enamel remineralization via poly(amido amine) and adhesive resin containing calcium phosphate nanoparticles

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dc.contributor.authorGao, Yuan
dc.contributor.authorLiang, Kunneng
dc.contributor.authorWeir, Michael D.
dc.contributor.authorGao, Jianghong
dc.contributor.authorImazato, Satoshi
dc.contributor.authorTay, Franklin R.
dc.contributor.authorLynch, Christopher D.
dc.contributor.authorOates, Thomas W.
dc.contributor.authorLi, Jiyao
dc.contributor.authorXu, Hockin H.K.
dc.contributor.funderNational Natural Science Foundation of Chinaen
dc.contributor.funderSichuan Province Science and Technology Support Programen
dc.contributor.funderFundamental Research Funds for Central Universities of the Central South Universityen
dc.contributor.funderResearch Fund of West China Hospitalen
dc.contributor.funderChina Postdoctoral Foundationen
dc.contributor.funderUniversity of Maryland, Baltimore Countyen
dc.contributor.funderSchool of Dentistry, University of Marylanden
dc.date.accessioned2021-11-18T11:45:05Z
dc.date.available2021-11-18T11:45:05Z
dc.date.issued2019-12-11
dc.description.abstractObjectives:The objective of this study was to investigate enamel remineralization using salivary statherin pro-tein-inspired poly(amidoamine) dendrimer (SN15-PAMAM) and adhesive containing nanoparticles of amor-phous calcium phosphate (NACP) in a cyclic artificial saliva/demineralizing solution for thefirst time.Methods:The enamel shear bond strengths of NACP adhesives were measured compared to commercial adhesive(Scotchbond Multi-Purpose, 3 M). Adhesive disks containing NACP were tested for calcium (Ca) and phosphorus(P) ions release. Four groups were tested: (1) enamel control, (2) enamel with NACP, (3) enamel with SN15-PAMAM, and (4) enamel with SN15-PAMAM + NACP. The specimens were treated with cyclic artificial saliva/demineralizing solution for 28 days. The remineralized enamel specimens were examined by surface and cross-sectional hardness test.Results:NACP adhesive yielded a similar shear bond strength to commercial control (Scotchbond Multi-Purpose,3 M). NACP adhesive released high levels of Ca and P ions. At 28 days, the enamel hardness of SN15-PAMAM +NACP group was 2.89 ± 0.13 GPa, significantly higher than that of control group (1.46 ± 0.10 GPa) (p< 0.05).SN15-PAMAM + NACP increased the enamel cross-sectional hardness at 28 days; at 25μm, enamel cross-sectional hardness was 90 % higher than that of control group (p< 0.05).Significance:The novel SN15-PAMAM + NACP adhesive method could achieve 90 % higher enamel reminer-alization of the artificial caries than the control under acid challenge for thefirst time. This method is promisingfor use after tooth cavity preparation, or as a coating on enamel with white spot lesions (WSLs) for prevention, toreduce secondary caries, prevent caries procession and protect tooth structures.en
dc.description.sponsorshipNational Natural Science Foundation of China (81670977 (L.J.Y.) and 81800965 (L.K.N.)); Sichuan Province Science and Technology Support Program (Grant No. 2017SZ0030); Fundamental Research Funds for Central Universities of the Central South University (2018SCU12016 (L.K.N.)); Research Fund of West China Hospital (<GN4>WCHS-201705</GN4> (L.K.N.)); China Postdoctoral Foundation (2018M643507 (L.K.N.))en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid103262en
dc.identifier.citationSemple, C. J., Rutherford, H., Killough, S., Moore, C. and McKenna, G. (2019) 'Enamel remineralization via poly(amido amine) and adhesive resin containing calcium phosphate nanoparticles', Journal of Dentistry, 92, 103262 (8pp). doi:10.1016/j.jdent.2019.103262en
dc.identifier.doi10.1016/j.jdent.2019.103262en
dc.identifier.endpage8en
dc.identifier.issn0300-5712
dc.identifier.journaltitleJournal of Dentistryen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/12227
dc.identifier.volume92en
dc.language.isoenen
dc.publisherElsevieren
dc.rights© 2019 Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 licenseen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectEnamel remineralizationen
dc.subjectStatherin protein poly(amidoamine) dendrimeren
dc.subjectAdhesiveen
dc.subjectpH cyclingen
dc.subjectNano-calcium phosphateen
dc.subjectEnamel hardnessen
dc.titleEnamel remineralization via poly(amido amine) and adhesive resin containing calcium phosphate nanoparticlesen
dc.typeArticle (peer-reviewed)en
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