Enamel remineralization via poly(amido amine) and adhesive resin containing calcium phosphate nanoparticles
dc.contributor.author | Gao, Yuan | |
dc.contributor.author | Liang, Kunneng | |
dc.contributor.author | Weir, Michael D. | |
dc.contributor.author | Gao, Jianghong | |
dc.contributor.author | Imazato, Satoshi | |
dc.contributor.author | Tay, Franklin R. | |
dc.contributor.author | Lynch, Christopher D. | |
dc.contributor.author | Oates, Thomas W. | |
dc.contributor.author | Li, Jiyao | |
dc.contributor.author | Xu, Hockin H.K. | |
dc.contributor.funder | National Natural Science Foundation of China | en |
dc.contributor.funder | Sichuan Province Science and Technology Support Program | en |
dc.contributor.funder | Fundamental Research Funds for Central Universities of the Central South University | en |
dc.contributor.funder | Research Fund of West China Hospital | en |
dc.contributor.funder | China Postdoctoral Foundation | en |
dc.contributor.funder | University of Maryland, Baltimore County | en |
dc.contributor.funder | School of Dentistry, University of Maryland | en |
dc.date.accessioned | 2021-11-18T11:45:05Z | |
dc.date.available | 2021-11-18T11:45:05Z | |
dc.date.issued | 2019-12-11 | |
dc.description.abstract | Objectives:The objective of this study was to investigate enamel remineralization using salivary statherin pro-tein-inspired poly(amidoamine) dendrimer (SN15-PAMAM) and adhesive containing nanoparticles of amor-phous calcium phosphate (NACP) in a cyclic artificial saliva/demineralizing solution for thefirst time.Methods:The enamel shear bond strengths of NACP adhesives were measured compared to commercial adhesive(Scotchbond Multi-Purpose, 3 M). Adhesive disks containing NACP were tested for calcium (Ca) and phosphorus(P) ions release. Four groups were tested: (1) enamel control, (2) enamel with NACP, (3) enamel with SN15-PAMAM, and (4) enamel with SN15-PAMAM + NACP. The specimens were treated with cyclic artificial saliva/demineralizing solution for 28 days. The remineralized enamel specimens were examined by surface and cross-sectional hardness test.Results:NACP adhesive yielded a similar shear bond strength to commercial control (Scotchbond Multi-Purpose,3 M). NACP adhesive released high levels of Ca and P ions. At 28 days, the enamel hardness of SN15-PAMAM +NACP group was 2.89 ± 0.13 GPa, significantly higher than that of control group (1.46 ± 0.10 GPa) (p< 0.05).SN15-PAMAM + NACP increased the enamel cross-sectional hardness at 28 days; at 25μm, enamel cross-sectional hardness was 90 % higher than that of control group (p< 0.05).Significance:The novel SN15-PAMAM + NACP adhesive method could achieve 90 % higher enamel reminer-alization of the artificial caries than the control under acid challenge for thefirst time. This method is promisingfor use after tooth cavity preparation, or as a coating on enamel with white spot lesions (WSLs) for prevention, toreduce secondary caries, prevent caries procession and protect tooth structures. | en |
dc.description.sponsorship | National Natural Science Foundation of China (81670977 (L.J.Y.) and 81800965 (L.K.N.)); Sichuan Province Science and Technology Support Program (Grant No. 2017SZ0030); Fundamental Research Funds for Central Universities of the Central South University (2018SCU12016 (L.K.N.)); Research Fund of West China Hospital (<GN4>WCHS-201705</GN4> (L.K.N.)); China Postdoctoral Foundation (2018M643507 (L.K.N.)) | en |
dc.description.status | Peer reviewed | en |
dc.description.version | Accepted Version | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.articleid | 103262 | en |
dc.identifier.citation | Semple, C. J., Rutherford, H., Killough, S., Moore, C. and McKenna, G. (2019) 'Enamel remineralization via poly(amido amine) and adhesive resin containing calcium phosphate nanoparticles', Journal of Dentistry, 92, 103262 (8pp). doi:10.1016/j.jdent.2019.103262 | en |
dc.identifier.doi | 10.1016/j.jdent.2019.103262 | en |
dc.identifier.endpage | 8 | en |
dc.identifier.issn | 0300-5712 | |
dc.identifier.journaltitle | Journal of Dentistry | en |
dc.identifier.startpage | 1 | en |
dc.identifier.uri | https://hdl.handle.net/10468/12227 | |
dc.identifier.volume | 92 | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.rights | © 2019 Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en |
dc.subject | Enamel remineralization | en |
dc.subject | Statherin protein poly(amidoamine) dendrimer | en |
dc.subject | Adhesive | en |
dc.subject | pH cycling | en |
dc.subject | Nano-calcium phosphate | en |
dc.subject | Enamel hardness | en |
dc.title | Enamel remineralization via poly(amido amine) and adhesive resin containing calcium phosphate nanoparticles | en |
dc.type | Article (peer-reviewed) | en |