Ultrasonically powered compact implantable dust for optogenetics

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dc.contributor.authorLaursen, Kjeld
dc.contributor.authorRashidi, Amin
dc.contributor.authorHosseini, Seyedsina
dc.contributor.authorMondal, Tanmay
dc.contributor.authorCorbett, Brian
dc.contributor.authorMoradi, Farshad
dc.contributor.funderHorizon 2020en
dc.date.accessioned2020-07-29T11:27:52Z
dc.date.available2020-07-29T11:27:52Z
dc.date.issued2020-04-03
dc.date.updated2020-07-29T11:16:01Z
dc.description.abstractThis paper presents an ultrasonically powered microsystem for deep tissue optogenetic stimulation. All the phases in developing the prototype starting from modelling the piezoelectric crystal used for energy harvesting, design, simulation and measurement of the chip, and finally testing the whole system in a mimicking setup are explained. The developed system is composed of a piezoelectric harvesting cube, a rectifier chip, and a micro-scale custom-designed light-emitting-diode (LED), and envisioned to be used for freely moving animal studies. The proposed rectifier chip with a silicon area of 300 μm × 300 μm is implemented in standard TSMC 0.18 μm CMOS technology, for interfacing the piezoelectric cube and the microLED. Experimental results show that the proposed microsystem produces an available electrical power of 2.2 mW while loaded by a microLED, out of an acoustic intensity of 7.2 mW/mm 2 using a (1 mm) 3 crystal as the receiver. The whole system including the tested rectifier chip, a piezoelectric cube with the dimensions of (500 μm) 3 , and a μLED of 300 μm × 130 μm have been integrated on a 3 mm × 1.5 mm glass substrate, encapsulated inside a bio-compatible PDMS layer and tested successfully for final prototyping. The total volume of the fully-packaged device is estimated around 2.85 mm 3.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationLaursen, K., Rashidi, A., Hosseini, S., Mondal, T., Corbett, B. and Moradi, F. (2020) 'Ultrasonically powered compact implantable dust for optogenetics', IEEE Transactions on Biomedical Circuits and Systems, 14(3), pp. 583-594. doi: 10.1109/TBCAS.2020.2984921en
dc.identifier.doi10.1109/TBCAS.2020.2984921en
dc.identifier.eissn1940-9990
dc.identifier.endpage594en
dc.identifier.issn1932-4545
dc.identifier.issued3en
dc.identifier.journaltitleIEEE Transactions on Biomedical Circuits and Systemsen
dc.identifier.startpage583en
dc.identifier.urihttps://hdl.handle.net/10468/10326
dc.identifier.volume14en
dc.language.isoenen
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::RIA/767092/EU/in vivo optogeneticS, elecTrophysiology and phArmacology with an ultRasonically-powered DUST for Parkinson's Disease/STARDUSTen
dc.rights© 2020, IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.en
dc.subjectBiomedical electronicsen
dc.subjectCMOS integrated circuitsen
dc.subjectEnergy harvestingen
dc.subjectLight emitting diodesen
dc.subjectMicromechanical devicesen
dc.subjectRectifiersen
dc.subjectUltrasonic therapyen
dc.subjectElectrical poweren
dc.subjectMicroscale custom-designed light-emitting-diodeen
dc.subjectPiezoelectric harvesting cubeen
dc.subjectPiezoelectric crystalen
dc.subjectDeep tissue optogenetic stimulationen
dc.subjectUltrasonically powered microsystemen
dc.subjectOptogeneticsen
dc.subjectPowered compact implantable dusten
dc.subjectTested rectifier chipen
dc.subjectPiezoelectric cubeen
dc.subjectTSMC CMOS technologyen
dc.subjectCrystalsen
dc.subjectIntegrated circuit modelingen
dc.subjectAcousticsen
dc.subjectComputational modelingen
dc.subjectCapacitorsen
dc.subjectFinite element analysisen
dc.subjectCMOSen
dc.subjectImplantable devicesen
dc.subjectPiezoelectricen
dc.subjectRectifieren
dc.subjectUltrasonic poweringen
dc.titleUltrasonically powered compact implantable dust for optogeneticsen
dc.typeArticle (peer-reviewed)en
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