Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid
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Finucane, Orla M.
Lynch, Marina A.
BioMed Central Ltd.
Microglia are multifunctional cells that are primarily neuroprotective and a deficit in their functional integrity is likely to be a contributory factor in the deteriorating neuronal function that occurs with age and neurodegeneration. One aspect of microglial dysfunction is reduced phagocytosis, and this is believed to contribute to the accumulation of amyloid-β (Aβ) in Alzheimer’s disease (AD). Therefore, improving phagocytosis should be beneficial in limiting the amyloidosis that characterises AD.
Toll-like receptor 2 (TLR2) , Amyloid-β (Aβ) , Microglia , Neuroinflammation , Glycolysis , Oxidative metabolism , Phagocytosis
Rubio-Araiz, A., Finucane, O.M., Keogh, S. and Lynch, M.A., 2018. Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid. Journal of neuroinflammation, 15(1), 247, (13 pp.). DOI:10.1186/s12974-018-1281-7
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