dc.contributor.author	Rubio-Araiz, Ana
dc.contributor.author	Finucane, Orla M.
dc.contributor.author	Keogh, Samuel
dc.contributor.author	Lynch, Marina A.
dc.contributor.funder	Science Foundation Ireland	en
dc.date.accessioned	2019-10-28T08:16:47Z
dc.date.available	2019-10-28T08:16:47Z
dc.date.issued	2018-08-31
dc.description.abstract	Microglia are multifunctional cells that are primarily neuroprotective and a deficit in their functional integrity is likely to be a contributory factor in the deteriorating neuronal function that occurs with age and neurodegeneration. One aspect of microglial dysfunction is reduced phagocytosis, and this is believed to contribute to the accumulation of amyloid-β (Aβ) in Alzheimer’s disease (AD). Therefore, improving phagocytosis should be beneficial in limiting the amyloidosis that characterises AD.	en
dc.description.sponsorship	Science Foundation Ireland (15/iA/3052, 11PI/10154)	en
dc.description.status	Peer reviewed	en
dc.description.version	Published Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.articleid	247	en
dc.identifier.citation	Rubio-Araiz, A., Finucane, O.M., Keogh, S. and Lynch, M.A., 2018. Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid. Journal of neuroinflammation, 15(1), 247, (13 pp.). DOI:10.1186/s12974-018-1281-7	en
dc.identifier.doi	10.1186/s12974-018-1281-7	en
dc.identifier.eissn	1742-2094
dc.identifier.endpage	13	en
dc.identifier.issued	1	en
dc.identifier.journaltitle	Journal of Neuroinflammation	en
dc.identifier.startpage	1	en
dc.identifier.uri	https://hdl.handle.net/10468/8902
dc.identifier.volume	15	en
dc.language.iso	en	en
dc.publisher	BioMed Central Ltd.	en
dc.relation.uri	https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-018-1281-7
dc.rights	© The Author(s). 2018, Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.	en
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	en
dc.subject	Toll-like receptor 2 (TLR2)	en
dc.subject	Amyloid-β (Aβ)	en
dc.subject	Microglia	en
dc.subject	Neuroinflammation	en
dc.subject	Glycolysis	en
dc.subject	Oxidative metabolism	en
dc.subject	Phagocytosis	en
dc.title	Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid	en
dc.type	Article (peer-reviewed)	en

Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid

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