Synthesis of fluorinated oxygen- and sulfur-containing heteroaromatics

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dc.contributor.authorLeary, Eileen M.
dc.contributor.authorJones, David J.
dc.contributor.authorO'Donovan, Fiona P.
dc.contributor.authorO'Sullivan, Timothy P.
dc.contributor.funderIrish Research Councilen
dc.contributor.funderUniversity College Corken
dc.date.accessioned2017-06-20T15:36:58Z
dc.date.available2017-06-20T15:36:58Z
dc.date.issued2015-06-11
dc.date.updated2017-06-20T11:03:21Z
dc.description.abstractMilk protein concentrate (79% protein) reconstituted at 13.5% (w/v) protein was heated (90 °C, 25 min, pH 7.2) with or without added calcium chloride. After fractionation of the casein and whey protein aggregates by fast protein liquid chromatography, the heat stability (90 °C, up to 1 h) of the fractions (0.25%, w/v, protein) was assessed. The heat-induced aggregates were composed of whey protein and casein, in whey protein:casein ratios ranging from 1:0.5 to 1:9. The heat stability was positively correlated with the casein concentration in the samples. The samples containing the highest proportion of caseins were the most heat-stable, and close to 100% (w/w) of the aggregates were recovered post-heat treatment in the supernatant of such samples (centrifugation for 30 min at 10,000 × g). κ-Casein appeared to act as a chaperone controlling the aggregation of whey proteins, and this effect was stronger in the presence of αS- and β-casein.en
dc.description.sponsorshipUniversity College Cork (Strategic Research Fund)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationO’Leary, E. M., Jones, D. J., O’Donovan, F. P. and O'Sullivan, T. P. (2015) 'Synthesis of fluorinated oxygen- and sulfur-containing heteroaromatics', Journal of Fluorine Chemistry, 176, pp. 93-120. doi: 10.1016/j.jfluchem.2015.06.002en
dc.identifier.doidoi:10.1016/j.jfluchem.2015.06.002
dc.identifier.endpage120en
dc.identifier.issn0022-1139
dc.identifier.journaltitleJournal of Fluorine Chemistryen
dc.identifier.startpage93en
dc.identifier.urihttps://hdl.handle.net/10468/4118
dc.identifier.volume176en
dc.language.isoenen
dc.publisherElsevieren
dc.rights© 2015 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 licenseen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectOrganofluorine chemistryen
dc.subjectFluorobenzofuransen
dc.subjectFluoropyronesen
dc.subjectFluorocoumarinsen
dc.subjectFluoroflavonesen
dc.subjectFluorochromonesen
dc.subjectFluoroxanthonesen
dc.subjectFluorothiophenesen
dc.subjectFluorobenzothiophenesen
dc.titleSynthesis of fluorinated oxygen- and sulfur-containing heteroaromaticsen
dc.typeArticle (peer-reviewed)en
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