Different effects of different Lactobacillus acidophilus strains on DSS-induced colitis

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dc.contributor.authorHuang, Zheng
dc.contributor.authorGong, Lei
dc.contributor.authorJin, Yan
dc.contributor.authorStanton, Catherine
dc.contributor.authorRoss, R. Paul
dc.contributor.authorZhao, Jianxin
dc.contributor.authorYang, Bo
dc.contributor.authorChen, Wei
dc.contributor.funderNational Natural Science Foundation of Chinaen
dc.contributor.funder111 projecten
dc.contributor.funderCollaborative Innovationcenter of Food Safety and Quality Control in Jiangsu Provinceen
dc.date.accessioned2023-03-10T13:35:54Z
dc.date.available2023-03-10T13:35:54Z
dc.date.issued2022-12
dc.date.updated2023-03-10T13:15:23Z
dc.description.abstractInflammatory bowel disease (IBD) is a worldwide chronic intestinal inflammatory immune-related disease. In this study, mice with dextran sulfate sodium (DSS)-induced colitis were used to evaluate the effect of Lactobacillus acidophilus on colitis. The results revealed that L. acidophilus CCFM137 and FAHWH11L56 show potential for relieving colitis symptoms, while L. acidophilus FGSYC48L79 did not show a protective effect. Moreover, L. acidophilus NCFM and FAHWH11L56 showed similar effects on various indicators of DSS-induced colitis, increasing the IL-10 and IL-17 in the colon, and modifying the CCL2/CCR2 axis and CCL3/CCR1 axis. For L. acidophilus CCFM137, its effects on colitis were different from the above two strains. Moreover, L. acidophilus FGSYC48L79 had negative effects on colitis by increasing the abundance of harmful bacteria in the gut microbiota and may promote the signaling of chemokines and their receptors. This may be related to its special genome compared to the other strains.en
dc.description.sponsorshipNational Natural Science Foundation of China (Nos. 32021005, 31820103010); 111 project (Grant BP0719028)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid14841en
dc.identifier.citationHuang, Z., Gong, L., Jin, Y., Stanton, C., Ross, R. P., Zhao, J., Yang, B. and Chen, W. (2022) ‘Different effects of different lactobacillus acidophilus strains on DSS-induced colitis’, International Journal of Molecular Sciences, 23(23), 14841 (18pp). doi: 10.3390/ijms232314841en
dc.identifier.doi10.3390/ijms232314841en
dc.identifier.endpage18en
dc.identifier.issn1422-0067
dc.identifier.issued23en
dc.identifier.journaltitleInternational Journal of Molecular Sciencesen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/14302
dc.identifier.volume23en
dc.language.isoenen
dc.publisherMDPIen
dc.rights© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectInduced ulcerative-colitisen
dc.subjectDextran sulfate sodiumen
dc.subjectColorectal carcinogenesisen
dc.subjectEscherichia-colien
dc.subjectGut microbiotaen
dc.subjectInflammationen
dc.subjectMetabolismen
dc.subjectReceptoren
dc.subjectMetastasisen
dc.subjectSignatureen
dc.titleDifferent effects of different Lactobacillus acidophilus strains on DSS-induced colitisen
dc.typeArticle (peer-reviewed)en
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