The sound of tablets during coating erosion, disintegration, deaggregation and dissolution

dc.contributor.authorO'Mahoney, Niamh
dc.contributor.authorKeating, John J.
dc.contributor.authorMcSweeney, Seán
dc.contributor.authorHill, Sam
dc.contributor.authorLawrence, Simon E.
dc.contributor.authorFitzpatrick, Dara
dc.contributor.funderNational University of Irelanden
dc.date.accessioned2020-04-15T14:26:25Z
dc.date.available2020-04-15T14:26:25Z
dc.date.issued2020-03-09
dc.date.updated2020-04-15T14:17:23Z
dc.description.abstractThis research aims to address a gap in our understanding of the mechanisms by which pharmaceutical tablets achieve highly reproducible and predictable drug release. The present industrial and regulatory practice is centred around tablet dissolution, i.e. what follows disintegration, yet the vast majority of problems that are found in formulation dissolution testing can be traced back to the erratic disintegration behaviour of the medicinal product. It is only due to the distinct lack of quantitative measurement techniques for disintegration analysis that this situation arises. Current methods involve costly, and time-consuming test equipment, resulting in a need for more simple, green and efficient methods which have the potential to enable rapid development and to accelerate routine solid drug formulation dissolution and disintegration testing. In this study, we present a novel approach to track several sequential tablet dissolution processes, including coating erosion, disintegration, deaggregation and dissolution using Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS). BARDS, in combination with minimal usage of UV spectroscopy, can effectively track these processes. The data also show that a solid oral dose formulation has an intrinsic acoustic signature which is specific to the method of manufacture and excipient composition.en
dc.description.sponsorshipNational University of Ireland (Awards for PhD funding)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid119216en
dc.identifier.citationO'Mahoney, N., Keating, J. J., McSweeney, S., Hill, S., Lawrence, S. E. and Fitzpatrick, D. (2020) 'The sound of tablets during coating erosion, disintegration, deaggregation and dissolution', International Journal of Pharmaceutics, 580, 119216 (10 pp). doi: 10.1016/j.ijpharm.2020.119216en
dc.identifier.doi10.1016/j.ijpharm.2020.119216en
dc.identifier.endpage10en
dc.identifier.issn0378-5173
dc.identifier.journaltitleInternational Journal of Pharmaceuticsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9832
dc.identifier.volume580en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0378517320302003
dc.rights© 2020 Elsevier B. V. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectBARDSen
dc.subjectDisintegrationen
dc.subjectDissolutionen
dc.subjectEDDDI ploten
dc.subjectEnteric coatingen
dc.subjectPantoprazoleen
dc.subjectReal-time release testen
dc.titleThe sound of tablets during coating erosion, disintegration, deaggregation and dissolutionen
dc.typeArticle (peer-reviewed)en
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