Semaphorin 6A knockout mice display abnormalities across ethologically-based topographies of exploration and in motor learning

dc.check.date2018-01-18
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisher.en
dc.contributor.authorHåkansson, Kerstin
dc.contributor.authorRunker, Annette
dc.contributor.authorO'Sullivan, Gerard J.
dc.contributor.authorMitchell, Kevin J.
dc.contributor.authorWaddington, John L.
dc.contributor.authorO'Tuathaigh, Colm M. P.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHealth Research Boarden
dc.contributor.funderIrish Research Council for Science, Engineering and Technologyen
dc.date.accessioned2017-08-11T08:41:03Z
dc.date.available2017-08-11T08:41:03Z
dc.date.issued2017-01-18
dc.date.updated2017-08-11T08:29:03Z
dc.description.abstractSemaphorins are secreted or membrane-bound proteins implicated in neurodevelopmental processes of axon guidance and cell migration. Exploratory behaviour and motor learning was examined ethologically in Semaphorin 6A (Sema6A) mutant mice. The ethogram of initial exploration in Sema6A knockout mice was characterised by increased rearing to wall with decreased sifting; over subsequent habituation, locomotion, sniffing and rearing to wall were increased, with reduced habituation of rearing seated. Rotarod analysis indicated delayed motor learning in Sema6A heterozygous mutants. Disruption to the axonal guidance and cell migration processes regulated by Sema6A is associated with topographically specific disruption to fundamental aspects of behaviour, namely the ethogram of initial exploration and subsequent habituation to the environment, and motor learning.en
dc.description.sponsorshipScience Foundation Ireland (Principal Investigator Grant 07/IN.1/B960); Health Research Board (Postdoctoral Fellowship PD/2007/20); Irish Research Council for Science, Engineering and Technology (Postdoctoral Fellowship)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHåkansson, K., Runker, A., O'Sullivan, G. J., Mitchell, K. J., Waddington, J. L. and O'Tuathaigh, C. M. P. (2017) 'Semaphorin 6A knockout mice display abnormalities across ethologically-based topographies of exploration and in motor learning', Neuroscience Letters, 641, pp. 70-76. doi:10.1016/j.neulet.2017.01.043en
dc.identifier.doi10.1016/j.neulet.2017.01.043
dc.identifier.endpage76en
dc.identifier.issn0304-3940
dc.identifier.journaltitleNeuroscience Lettersen
dc.identifier.startpage70en
dc.identifier.urihttps://hdl.handle.net/10468/4458
dc.identifier.volume641en
dc.language.isoenen
dc.publisherElsevier Ltden
dc.rights© 2017 Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectSemaphorin 6Aen
dc.subjectKnockout miceen
dc.subjectBehavioural phenotypeen
dc.subjectEthogramen
dc.subjectMotor learningen
dc.titleSemaphorin 6A knockout mice display abnormalities across ethologically-based topographies of exploration and in motor learningen
dc.typeArticle (peer-reviewed)en
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