Plant glycan metabolism by bifidobacteria

dc.contributor.authorKelly, Sandra M.en
dc.contributor.authorMunoz-Munoz, Joseen
dc.contributor.authorvan Sinderen, Douween
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderNorthumbria Universityen
dc.date.accessioned2023-11-15T12:29:35Z
dc.date.available2023-11-15T12:29:35Z
dc.date.issued2021en
dc.description.abstractMembers of the genus Bifidobacterium of which the majority have been isolated as gut commensals, are Gram-positive, non-motile, saccharolytic, non-sporulating, anaerobic bacteria. Many bifidobacterial strains are considered probiotic and therefore are thought to bestow health benefits upon their host. Bifidobacteria are highly abundant among the gut microbiota of healthy, full term, breast-fed infants, yet the relative average abundance of bifidobacteria tends to decrease as the human host ages. Because of the inverse correlation between bifidobacterial abundance/prevalence and health, there has been an increasing interest in maintaining, increasing or restoring bifidobacterial populations in the infant, adult and elderly gut. In order to colonize and persist in the gastrointestinal environment, bifidobacteria must be able to metabolise complex dietary and/or host-derived carbohydrates, and be resistant to various environmental challenges of the gut. This is not only important for the autochthonous bifidobacterial species colonising the gut, but also for allochthonous bifidobacteria provided as probiotic supplements in functional foods. For example, Bifidobacterium longum subsp. longum is a taxon associated with the metabolism of plant-derived poly/oligosaccharides in the adult diet, being capable of metabolising hemicellulose and various pectin-associated glycans. Many of these plant glycans are believed to stimulate the metabolism and growth of specific bifidobacterial species and are for this reason classified as prebiotics. In this review, bifidobacterial carbohydrate metabolism, with a focus on plant poly-/oligosaccharide degradation and uptake, as well as its associated regulation, will be discussed.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid609418en
dc.identifier.citationKelly, S.M., Munoz-Munoz, J. and Van Sinderen, D. (2021) ‘Plant glycan metabolism by bifidobacteria’, Frontiers in Microbiology, 12, 609418 (18pp). doi: 10.3389/fmicb.2021.609418.en
dc.identifier.doi10.3389/fmicb.2021.609418en
dc.identifier.endpage18en
dc.identifier.issn1664-302Xen
dc.identifier.journaltitleFrontiers in Microbiologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/15230
dc.identifier.volume12en
dc.language.isoenen
dc.publisherFrontiers Media S.A.en
dc.relation.ispartofFrontiers in Microbiologyen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rights© 2021 Kelly, Munoz-Munoz and van Sinderen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectBifidobacteriaen
dc.subjectPlant glycansen
dc.subjectPlant oligosaccharidesen
dc.subjectFiberen
dc.subjectGlycosyl hydrolaseen
dc.subjectCAZy enzymesen
dc.subjectCarbohydrate metabolismen
dc.titlePlant glycan metabolism by bifidobacteriaen
dc.typeArticle (peer-reviewed)en
dc.typejournal-articleen
oaire.citation.volume12en
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