dc.contributor.author	Kentner, Amanda C.
dc.contributor.author	Cryan, John F.
dc.contributor.author	Brummelte, Susanne
dc.contributor.funder	National Institute of Mental Health	en
dc.contributor.funder	Science Foundation Ireland	en
dc.date.accessioned	2018-11-27T11:23:17Z
dc.date.available	2018-11-27T11:23:17Z
dc.date.issued	2018-10-11
dc.date.updated	2018-11-27T10:14:47Z
dc.description.abstract	Despite the increasing attention to early life adversity and its long-term consequences on health, behavior, and the etiology of neurodevelopmental disorders, our understanding of the adaptations and interventions that promote resiliency and rescue against such insults are underexplored. Specifically, investigations of the perinatal period often focus on negative events/outcomes. In contrast, positive experiences (i.e. enrichment/parental care//healthy nutrition) favorably influence development of the nervous and endocrine systems. Moreover, some stressors result in adaptations and demonstrations of later-life resiliency. This review explores the underlying mechanisms of neuroplasticity that follow some of these early life experiences and translates them into ideas for interventions in pediatric settings. The emerging role of the gut microbiome in mediating stress susceptibility is also discussed. Since many negative outcomes of early experiences are known, it is time to identify mechanisms and mediators that promote resiliency against them. These range from enrichment, quality parental care, dietary interventions and those that target the gut microbiota.	en
dc.description.sponsorship	National Institute of Mental Health (Award No. R15MH114035)	en
dc.description.status	Peer reviewed	en
dc.description.version	Accepted Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Kentner, A. C., Cryan, J. F. and Brummelte, S. (2018) 'Resilience priming: Translational models for understanding resiliency and adaptation to early life adversity', Developmental Psychobiology, In Press, doi: 10.1002/dev.21775	en
dc.identifier.doi	10.1002/dev.21775
dc.identifier.endpage	26	en
dc.identifier.issn	1098-2302
dc.identifier.issued	0	en
dc.identifier.journaltitle	Developmental psychobiology	en
dc.identifier.startpage	1	en
dc.identifier.uri	https://hdl.handle.net/10468/7150
dc.identifier.volume	0	en
dc.language.iso	en	en
dc.publisher	Wiley	en
dc.relation.project	info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/	en
dc.relation.uri	https://onlinelibrary.wiley.com/doi/abs/10.1002/dev.21775
dc.rights	© 2018 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Kentner AC, Cryan JF, Brummelte S. Resilience priming: Translational models for understanding resiliency and adaptation to early life adversity. Developmental Psychobiology. 2018; 00:1–26., which has been published in final form at https://doi.org/10.1002/dev.21775. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.	en
dc.subject	Early life adversity	en
dc.subject	Enrichment	en
dc.subject	Microbiome	en
dc.subject	Parental care resiliency	en
dc.subject	Translational research	en
dc.title	Resilience priming: translational models for understanding resiliency and adaptation to early life adversity	en
dc.type	Article (peer-reviewed)	en

Resilience priming: translational models for understanding resiliency and adaptation to early life adversity

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