Emerging applications of upconverting nanoparticles in intestinal infection and colorectal cancer

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dc.contributor.authorSingh, Raminder
dc.contributor.authorDumlupinar, Gokhan
dc.contributor.authorAndersson-Engels, Stefan
dc.contributor.authorMelgar, Silvia
dc.date.accessioned2019-11-23T06:34:26Z
dc.date.available2019-11-23T06:34:26Z
dc.date.issued2019-02-07
dc.description.abstractColorectal cancer is the abnormal growth of cells in colon or rectum. Recent findings have acknowledged the role of bacterial infection and chronic inflammation in colorectal cancer initiation and progression. In order to detect and treat precancerous lesions, new tools are required, which may help to prevent or identify colorectal cancer at an early stage. To date, several different screening tests are available, including endoscopy, stool-based blood tests, and radiology-based tests. However, these analyses either lack sensitivity or are of an invasive nature. The use of fluorescently labeled probes can increase the detection sensitivity. However, autofluorescence, photobleaching, and photodamage are commonly encountered problems with fluorescence imaging. Upconverting nanoparticles (UCNPs) are recently developed lanthanide-doped nanocrystals that can be used as light-triggered luminescent probes and in drug delivery systems. In this review, we comprehensively summarize the recent developments and address future prospects of UCNP-based applications for diagnostics and therapeutic approaches associated with intestinal infection and colorectal cancer.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSingh, R., Dumlupinar, G., Andersson-Engels, S. and Melgar, S., 2019. Emerging applications of upconverting nanoparticles in intestinal infection and colorectal cancer. International journal of nanomedicine, 14, (11pp). DOI:10.2147/IJN.S188887en
dc.identifier.doi10.2147/IJN.S188887en
dc.identifier.eissn1178-2013
dc.identifier.endpage1038en
dc.identifier.issn1176-9114
dc.identifier.journaltitleInternational Journal of Nanomedicineen
dc.identifier.startpage1027en
dc.identifier.urihttps://hdl.handle.net/10468/9189
dc.identifier.volume14en
dc.language.isoenen
dc.publisherNLM (Medline)en
dc.relation.urihttps://www.dovepress.com/emerging-applications-of-upconverting-nanoparticles-in-intestinal-infe-peer-reviewed-article-IJN
dc.rights© 2019 Singh et al. This work is published and licensed by Dove Medical Press Limiteden
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/en
dc.subjectNear infrareden
dc.subjectImagingen
dc.subjectBacteriaen
dc.subjectPhotodynamic therapyen
dc.subjectAnti-Stokes emissionen
dc.subjectInflammationen
dc.titleEmerging applications of upconverting nanoparticles in intestinal infection and colorectal canceren
dc.typeArticle (peer-reviewed)en
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