No neurodevelopmental benefit of cerebral oximetry in the first randomised trial (SafeBoosC II) in preterm infants during the first days of life

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dc.contributor.authorPlomgaard, Anne M.
dc.contributor.authorAlderliesten, Thomas
dc.contributor.authorvan Bel, Frank
dc.contributor.authorBenders, Manon
dc.contributor.authorClaris, Olivier
dc.contributor.authorCordeiro, Malaika
dc.contributor.authorDempsey, Eugene M.
dc.contributor.authorFumagalli, Monica
dc.contributor.authorGluud, Christian
dc.contributor.authorHyttel-Sorensen, Simon
dc.contributor.authorLemmers, Petra
dc.contributor.authorPellicer, Adelina
dc.contributor.authorPichler, Gerhard
dc.contributor.authorGreisen, Gorm
dc.contributor.funderStrategiske Forskningsråd
dc.date.accessioned2018-09-27T12:08:24Z
dc.date.available2018-09-27T12:08:24Z
dc.date.issued2018
dc.description.abstractAim: Cerebral hypoxia has been associated with neurodevelopmental impairment. We studied whether reducing cerebral hypoxia in extremely preterm infants during the first 72 hours of life affected neurological outcomes at two years of corrected age. Methods: In 2012‐2013, the phase II randomised Safeguarding the Brains of our smallest Children trial compared visible cerebral near‐infrared spectroscopy (NIRS) monitoring in an intervention group and blinded NIRS monitoring in a control group. Cerebral hy oxia was significantly reduced in the intervention group. We followed up 115 survivors from eight European centres at two years of corrected age, by conducting a medical examination and assessing their neurodevelopment with the Bayley Scales of Infant and Toddler Development, Second or Third Edition, and the parental Ages and Stages Questionnaire (ASQ). Results: There were no differences between the intervention (n = 65) and control (n = 50) groups with regard to the mean mental developmental index (89.6 ± 19.5 versus 88.4 ± 14.7, p = 0.77), ASQ score (215 ± 58 versus 213 ± 58, p = 0.88) and the number of children with moderate‐to‐severe neurodevelopmental impairment (10 versus six, p = 0.58). Conclusions: Cerebral NIRS monitoring was not associated with long‐term benefits or harm with regard to neurodevelopmental outcome at two years of corrected age.en
dc.description.sponsorshipStrategiske Forskningsråd (0603-00482B)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationPlomgaard, A. M., Alderliesten, T., van Bel, F., Benders, M., Claris, O., Cordeiro, M., Dempsey, E., Fumagalli, M., Gluud, C., Hyttel-Sorensen, S., Lemmers, P., Pellicer, A., Pichler, G. and Greisen, G. 'No neurodevelopmental benefit of cerebral oximetry in the first randomised trial (SafeBoosC II) in preterm infants during the first days of life', Acta Paediatrica. pp. 1-7. doi: 10.1111/apa.14463en
dc.identifier.doi10.1111/apa.14463
dc.identifier.endpage7
dc.identifier.issn0803-5253
dc.identifier.journaltitleActa Paediatrica, International Journal of Paediatricsen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/6945
dc.language.isoenen
dc.publisherWiley, Blackwell Publishing Ltden
dc.relation.urihttps://onlinelibrary.wiley.com/doi/abs/10.1111/apa.14463
dc.rights© 2018, the Authors. Acta Pædiatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Pædiatrica. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectAges and stages questionnaireen
dc.subjectbayley scales of infant and toddler developmenten
dc.subjectcerebral near‐infrared spectroscopyen
dc.subjectextremely preterm infantsen
dc.subjectneurodevelopmenten
dc.titleNo neurodevelopmental benefit of cerebral oximetry in the first randomised trial (SafeBoosC II) in preterm infants during the first days of lifeen
dc.typeArticle (peer-reviewed)en
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