Genetic tools for investigating the biology of commensal lactobacilli

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dc.contributor.authorFang, Fang
dc.contributor.authorO'Toole, Paul W.
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2010-02-09T10:01:37Z
dc.date.available2010-02-09T10:01:37Z
dc.date.copyright2009
dc.date.issued2009-01-01
dc.description.abstractLactobacilli belong to the genus Lactobacillus, the largest genus among the lactic acid bacteria (LAB). They are abundant in plant material and food resources, or they may inhabit niches in or on the bodies of humans and animals, as commensals. Lactobacilli of food origin are commercially important in the production of dairy products, fermented meats, vegetables, and sourdough, and many of their properties have been well studied. Commensal lactobacilli are good candidates for development as probiotics. In recent years, the general biology and host interaction mechanisms of commensal lactobacilli have attracted great interest. Although the metabolic pathways, predicted gene functions, and some phenotypic traits, of commensal lactobacilli can be inferred or deduced to an extent by the growing number of Lactobacillus genome sequencing project, various genetic tools are still required to confirm their phenotypic properties and biological traits. The current state of the art with respect to the available complement of genetic tools including genomic resources, and more traditional approaches to investigate the biology of commensal lactobacilli, will now be reviewed.en
dc.description.sponsorshipScience Foundation Ireland (Centre for Science, Engineering and Technology)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationFang F, O'Toole PW. (2009) Genetic tools for investigating the biology of commensal lactobacilli. Frontiers in Bioscience. 14 (1) 3111-3127.en
dc.identifier.doi10.2741/3439
dc.identifier.endpage3127en
dc.identifier.issn1093-9946
dc.identifier.issued1en
dc.identifier.journaltitleFrontiers in Bioscienceen
dc.identifier.startpage3111en
dc.identifier.urihttps://hdl.handle.net/10468/112
dc.identifier.volume14en
dc.language.isoenen
dc.publisherFrontiers in Bioscienceen
dc.relation.urihttp://www.bioscience.org/2009/v14/af/3439/fulltext.htm
dc.rights© Frontiers in Bioscienceen
dc.subjectLactobacillusen
dc.subjectProbioticsen
dc.subjectGenomicsen
dc.subjectGenetic Toolsen
dc.subjectReviewen
dc.subject.lcshLactobacillus -- Genetics -- Researchen
dc.subject.lcshLactic acid bacteriaen
dc.subject.meshGene Expression Regulationen
dc.subject.meshGener Transfer Techniquesen
dc.subject.meshGenome, Bacterialen
dc.subject.meshLactobacillus/geneticsen
dc.titleGenetic tools for investigating the biology of commensal lactobacillien
dc.typeArticle (peer-reviewed)en
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